Introduction: Multidrug resistance (MDR) is threatening the adequate coverage of antibiotics. This study aimed to analyze the antimicrobial resistance pattern of bacterial isolates from wound infection and the scenario of multidrug resistance. Methods: Microbiological culture results scripts of Medinova Medical Services LTD, representing non-repetitive various wound samples (post-surgical, trauma, superficial skin, burn) reported between January 2017 and March 2018, were retrieved and analyzed for pathogens and their antimicrobial resistance patterns using R version 3.5.3. Results: Overall, 1266 bacterial isolates were obtained, and 850 (67.1%) were identified as MDR. The percentage of MDR among gram-positive and gram-negative bacterial isolates were 68.8% and 66.0%, respectively. Among isolates Staphylococcus aureus (n = 401), Pseudomonas aeruginosa (n = 200), and Escherichia coli (n = 193) were predominant. Vancomycin followed linezolid showed most activity against gram-positive bacteria. Whereas, Colistin was found to be the most active against most of the gram-negative bacterium except for the Proteus spp in sensitivity test. Although, carbapenem group was determined to be the best against Proteus spp. About 82% Enterococcus spp and 76% Proteus spp were MDR. Isolates from patients aged >60 years (AOR = 1.774 95%CI: 1.089–2.892) were more prone to becoming MDR in compared to other age group and was a significant determinant (P = 0.02) of MDR. Conclusions: Our study revealed that the presence of MDR pathogens in wound infection was noteworthy. The findings of this study would assist in decision making of wound infection treatment. Highlights

Antimicrobial resistance is a major global public health challenge threatening the utility of antibiotics. Inappropriate antibiotic prescribing and sales, using outside of the health sectors, and genetic factors are mainly influencing the development of antimicrobial resistance (AMR). Antibiotics abuse in human, wildlife, and farming practices have an enormous health impact. Recently approved antibiotics are anticipated to help stem this crisis. To fight against antibiotic resistance crisis, development of collaboration among concerned stakeholders to establish policies, initiatives, and investments for new agents can be auspicious. New methods of antibacterial drug identification and strategies, neutralize virulence factors, are the substitute approaches to address the AMR threat. Some novel approaches have also been taken to develop alternatives to typical antibiotics for bacterial infection. Here, we tried to highlight some of the key reasons behind antibiotic resistance, management, and burden. Moreover, this paper also discusses recent developments in this area and a brief overview of future antibacterial agents. J MEDICINE JUL 2019; 20 (1) : 38-45