Fungal infections have become a major problem of worldwide concern. Yeasts belonging to the Candida genus and the pathogenic fungus Cryptococcus neoformans are responsible for different clinical manifestations, especially in immunocompromised patients. Antifungal therapies are currently based on a few chemotherapeutic agents that have problems related to effectiveness and resistance profiles. Microemulsions are isotropic, thermodynamically stable transparent systems of oil, water and surfactant that can improve the solubilization of lipophilic drugs. Taking into account the need for more effective and less toxic drugs along with the potential of thiophene derivatives as inhibitors of pathogenic fungi growth, this study aimed to evaluate the antifungal activity of a thiophene derivative (5CN05) embedded in a microemulsion (ME). The minimum inhibitory concentration (MIC) was determined using the microdilution method using amphotericin B as a control. The formulations tested (ME- blank and ME-5CN05) showed physico-chemical properties that would allow their use by the topical route. 5CN05 as such exhibited moderate or weak antifungal activity against Candida species (MIC = 270–540 μg.mL−1) and good activity against C. neoformans (MIC = 17 μg.mL−1). Candida species were susceptible to ME-5CN05 (70–140 μg.mL−1), but C. neoformans was much more, presenting a MIC value of 2.2 μg.mL−1. The results of this work proved promising for the pharmaceutical industry, because they suggest an alternative therapy against C. neoformans.

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: Surfactants are amphiphilic molecules of great interest in the pharmaceutical field due to their use in combination with other adjuvants to solubilize poor soluble drugs, improve their dissolution profile, promote permeation, increase drug delivery systems stabilization, among other characteristics. Literature shows that surfactants are included in several pharmaceutical forms composition: tablets, solid dispersions, emulsions, microemulsions, nanoemulsions, liposomes, and niosomes. This review aims to elucidate the different classes of surfactants based on their charges (cationic, anionic, nonionic, zwitterionic, and dimeric), the micelles formation process, and how surfactants molecules geometry can affect this phenomenon. Moreover, current studies regarding the benefits of surfactants in the development of formulations are presented. Finally, a discussion on how charges and chain length of surfactants can interact with the stratum corneum epithelial cells leading to increased permeation or skin irritability is reported.

The Psidium guajava is a species utilized traditionally to treat many pathologies for presenting a variety of phytochemicals, for: flavonoids, terpenoids, tannins, cineol, β-karyophylene. With the intent of exploring the pharmacological potential of P.guajava, its use for the creation of pharmaceutical products, an integrative review of the literature was made, using the guiding question: "How can the guava tree's therapeutic potential contribute to the development of new pharmaceutical products?". The searches ocurred in official documents and cientific articles indexed to the ANVISA data base of Scielo, PubMed and Lilacs, during the months of august and september of 2022. The describers used were: Phytotherapy, complementary therapies, Psidium, Therapeutic Action and Pharmaceutical Products being crossed with the help of operator And. Were considered as criteria of inclusion official documents and complete articles available for access, indexed to the aforementioned platforms, in english and portuguese, between 2012 and 2022, and as criteria of exclusion, duplicated studies, studies with thematic escape and that weren't available for access both free and in full, resulting in an atmosphere of 16 files. The researches has shown that the guava tree presents several therapeutic actions, such as: antioxidant, anti-inflammatory, photoprotective, antibacterial, anticariogenic, anti-tumor, antispasmodic, hypoglycemic, nephroprotective, anti-diarrheal, antinociceptive, healing, cytotoxic, and acts against dermatitis. Therefore, the bioactive compounds of this vegetable can be used for the development of pharmaceutical products with the purpose of expanding the therapeutic options in the market and optimize the patients' quality of life becoming fundamental to foster cientific researches that discuss about the safety, efficiency and toxicity of the using these metabolites.

A radiação solar é indispensável para vários processos biológicos, atua diretamente na estimulação dos melanócitos e como precursor da vitamina D. Entretanto, de acordo com o grau de exposição, vários são os danos que podem ser causados, como queimaduras, fotoenvelhecimento e câncer de pele. Desse modo, a busca por produtos de origem fitoquímica, apresentam um grande potencial para o descobrimento de vegetais com atividade fotoprotetora, e podem ser incorporados em formulações cosméticas aumentando a sua eficácia. Diante do exposto, o objetivo deste trabalho foi identificar os compostos fitoquímicos, extratos e frações vegetais que apresentam atividade fotoprotetora evidenciadas por testes in vitro e/ou in vivo comprovados na literatura. Tratou-se de um estudo que foi desenvolvido por meio de uma revisão integrativa da literatura entre os anos de 2011 e 2021, de modo a responder a seguinte pergunta norteadora: “Quais os compostos fitoquímicos apresentam atividade fotoprotera?” Os extratos vegetais são os compostos mais empregados nas pesquisas, a maioria dos estudos se objetivam em destacar o valor do Fator de Proteção Solar (FPS). Já os compostos isolados e as frações, estão mais associados ao sinergismo quando incorporados em produtos fotoprotetores. Em vista disso, a associação desses compostos aos filtros solares sintéticos, podem demandar menor toxicidade, uma vez que essas moléculas sintéticas podem causar muitos efeitos colaterais, e além de dificultar a adesão dos usuários, podem comprometer o aspecto saudável da pele. Portanto, o uso de produtos fitoquímicos surgem como uma alternativa promissora no desenvolvimento de formulações de proteção solar sustentáveis, eficazes e seguras.