Introduction. In patients with microcirculatory type of bleeding on the background of undifferentiated connective tissue dysplasia (UCTD), along with a tendency to bleeding, genetic predictors of thrombogenic risk are identified. Materials and methods. DNA samples of 92 adolescents (55 boys and 37 girls) aged from of 6 months to 18 years were used. The control group consisted of 115 children (I-II health groups). The analysis was based on the Real-Time PCR method using competing TagMan probes. The genetic testing of 12 allelic DNA polymorphisms was carried out. There was performed the analysis of laboratory and instrumental methods. The results were statistically processed with using the StatSoft Statistica 6.1 software package. Results. There was determined an increased prevalence of occurrence of the minor G(-455) allele of the gene of FGB fibrinogen, the minor allele (C807) of the gene of platelet receptor for ITGA2 collagen, and the rare homozygous 4G (-675) allele of the PAI-1 gene in patients compared with healthy children. Homozygous genotype (rare allele) 807TT of the ITGA2 gene of the platelet receptor for collagen and homozygous genotype 4G(-675)4G of the PAI-1 gene in patients with bleeding manifestations on the background of UCDT were detected significantly more often than in healthy children. In 76 (82.6%) children there were detected phenotypic signs of UCDT, their average number for each patient was of 3.2 ± 0.7. In the blood of sick children, there was a decrease in platelet aggregation by 2 and 3 inducers (epinephrine, ADP, collagen) and an increased concentration of homocysteine. Conclusion. The detection of hidden genetic predictors of thrombogenic risk in patients with microcirculatory type of bleeding against the background of UCDT is an indication for personification of treatment, since with an increase in the predictors of thrombophilia in such patients, the risk of thrombosis increases. In this case, the state of thrombotic or hemorrhagic predisposition should be determined in a timely manner, and hemostatic therapy with drugs that do not provoke thrombosis should be used against the background of angioprotectors.

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Introduction. One of the urgent problems of modern pediatrics is the risk of developing vascular complications in children, among which thrombosis is not uncommon. For early diagnosis and thromboprophylaxis of strokes and other vascular complications, the identification of thrombogenic risk factors is indicated. The purpose of the study. Based on the screening, to establish predictors of thrombogenic risk in children living in urban and rural areas of the Altai Territory for the timely prevention of vascular complications. Materials and methods. The results of a screening study of two hundred seventeen aged 12–17 years children living in the city of Barnaul, Zarinsk and Klyuchevsk districts of the Altai Territory, were analyzed. Screening examination of children without signs of thrombosis and bleeding was carried out at an outpatient appointment with a pediatrician in random sampling. The questionnaire included questions to clarify the family thrombotic history, personal thrombotic history, background somatic diseases. Clinical examination was performed for all interviewed patients. Results. According to the results of the study, it was revealed that in 65 (30%) of the 217 children surveyed, the closest relatives had thrombogenic risk factors, such as heart attacks, strokes, hypertension, coronary heart disease (CHD). After analyzing the personal thrombotic history, it was found that in the general group of patients, myocardial infarction was observed in 2 (0.9%) children. Strokes were noted in 5 (2.3%) respondents, and thrombosis and TIA in 2 (0.9%) subjects. When analyzing the results, it was found that a significant proportion of children had the following conditions, such as vegetative-vascular dystonia (VVD) of the hypertensive type, the presence of signs of undifferentiated connective tissue dysplasia (UCTD), smoking, obesity. Conclusion. According to screening data in children, the main predisposing factors in the development of thrombosis, strokes and heart attacks are a burdened family, thrombotic history, the presence of some somatic diseases. The combination of these factors justifies the need for additional examination for the prevention of vascular thrombosis.

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