Objective : The aim of this study was to find an alternative to the use of leaves of sweet potatoes (Ipomoea batatas (L.) Lam. ) in the diet of rabbits (Oryctolagus cuniculus L.) whose uncontrolled leaves harvesting can induce a decrease in production of tubers up to 32%. Methodology and Results: The effect of ingestion of guinea grass (Panicum maximum Jacq.) associated with milk weed (Euphorbia heterophylla) (Paneuph) or sweet potatoes (Ipomoea batatas) (Panipo) on daily weight gain and feed efficiency was determinate in rabbits. The weight a the birth and the end fattening (90 days old) were 67.6 g and 60.8 g and 770.0 and 933.8 g respectively for Panipo and Paneuph. The Paneuph diet induced a daily growth and a feed efficiency significantly higher in the last two months of the test. Conclusions and Application of Results: Results of this study indicated using of milk weed in substitution of leaves of sweet potatoes in rabbits feed could be considered.