Understanding value differences between generations will help nursing managers to develop more responsive work settings for nurses of all ages.

This article offers a constructive critique of the Copenhagen School's ‘securitization’ framework by applying it in an analysis of the role of international organizations seeking to counter the trafficking of narcotics and persons in post-Soviet Central Asia. The study discovers common and divergent motivations that explain international attempts and failures to securitize. In the case of human trafficking, significant clashes created obstacles to international efforts. In both cases, international organizations advanced their agendas through the language of security, but also through institutional changes and increased resource allocation. These processes led to the adoption of mostly traditional security strategies. The analysis concludes that although the securitization framework makes significant contributions as an analytical tool, its definition is too vague and it is too narrow in focus. ‘Security dichotomies’ need to be taken into account in a comprehensive analysis of why international attempts to securitize issues sometimes succeed and sometimes fail. The influence of rhetoric on the development of policy should also be taken into account if the securitization framework is to provide a complete understanding of the issues or be useful for policymakers.

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The physical association of regulatory enzymes and ion channels at relevant intracellular sites contributes to the diversity and specificity of second messenger-mediated signal transduction in cells. mAKAP is a scaffolding protein that targets the cAMP-dependent protein kinase A and phosphodiesterase type 4D3 to the nuclear envelope of differentiated cardiac myocytes. Here we present data that the mAKAP signaling complex also includes nuclear envelope-resident ryanodine receptors and protein phosphatase 2A. The ryanodine receptor is the major cardiac ion channel responsible for calcium-induced calcium release from intracellular calcium ion stores. As demonstrated by a combination of immunohistochemistry and tissue fractionation, mAKAP is targeted specifically to the nuclear envelope, whereas the ryanodine receptor is present at both the sarcoplasmic reticulum and nuclear envelope intracellular membrane compartments. At the nuclear envelope, a subset of cardiac ryanodine receptor is bound to mAKAP and via the association with mAKAP may be regulated by protein kinase A-mediated phosphorylation. By binding protein kinase A and ryanodine receptor, mAKAP may serve as the scaffold for a cAMP- and calcium ion-sensitive signaling complex.