To optimize the treatment of diseases which are accompanied by disorders of the psycho-emotional sphere, it is necessary to identify differences and expose the pathogenesis of these changes appearance depending on the primary pathology. During the study, changes in the components of behavior in the elevated plus maze were studied in rats with a developed explosion-induced neurotrauma (EINT), hyper- and hypothyroidism. The experiment conduc­ted on 33 Wistar rats, of which 12 sexually mature rats were divided into control and expe­rimental (with an established EINT) group, 21 young rats were divided into 3 groups – with hyperthyroidism, hypothyroidism and a control group. All animals were kept in standard conditions of the vivarium of the DSMU, the studies were carried out in accordance with the requirements of bioethics. Analysis of the results showed that under the action of various pathological factors, different behavioral profiles are formed, which indicate the development of a trivial state during stress-like reactions after neurotrauma or with an altered hormonal state. The behavioral profile of rats after reproduction of the EINT in comparison with the control group indicates the development of stress-like conditions (statistically significant (p≤0.05) increase in upright stands by 62%, an increase in the number of bowel movements by 50%. Hyperthyroidism is characterized by sympathetic nervous system activation, as evidenced by a significant (p≤0.05) increase in both the number of measures in the open sleeves by 70% and a significant (p≤0.05) increase in the time spent in light sleeves by 51%. In hypothyroidism, there is a suppression of the emotional component of the rats behavior, as evidenced by a significant (p≤0.05) reduction of measures by 63% and time spent in light sleeves by 86%, grooming duration by 71%, hanging from the edges of open sleeves by 80% and the number of bolus defecation by 100%. Keywords: thyroid gland, antigen, staphylococcal toxoid, mast cells, experiment, rats.

To optimize the treatment of diseases which are accompanied by disorders of the psycho-emotional sphere, it is necessary to identify differences and expose the pathogenesis of these changes appearance depending on the primary pathology. During the study, changes in the components of behavior in the elevated plus maze were studied in rats with a developed explosion-induced neurotrauma (EINT), hyper- and hypothyroidism. The experiment conduc­ted on 33 Wistar rats, of which 12 sexually mature rats were divided into control and expe­rimental (with an established EINT) group, 21 young rats were divided into 3 groups – with hyperthyroidism, hypothyroidism and a control group. All animals were kept in standard conditions of the vivarium of the DSMU, the studies were carried out in accordance with the requirements of bioethics. Analysis of the results showed that under the action of various pathological factors, different behavioral profiles are formed, which indicate the development of a trivial state during stress-like reactions after neurotrauma or with an altered hormonal state. The behavioral profile of rats after reproduction of the EINT in comparison with the control group indicates the development of stress-like conditions (statistically significant (p≤0.05) increase in upright stands by 62%, an increase in the number of bowel movements by 50%. Hyperthyroidism is characterized by sympathetic nervous system activation, as evidenced by a significant (p≤0.05) increase in both the number of measures in the open sleeves by 70% and a significant (p≤0.05) increase in the time spent in light sleeves by 51%. In hypothyroidism, there is a suppression of the emotional component of the rats behavior, as evidenced by a significant (p≤0.05) reduction of measures by 63% and time spent in light sleeves by 86%, grooming duration by 71%, hanging from the edges of open sleeves by 80% and the number of bolus defecation by 100%. Keywords: thyroid gland, antigen, staphylococcal toxoid, mast cells, experiment, rats.

The mild blast-induced brain traumatic injury like a battle fatigue, leads to neurological disability, including due to a violation of spatial memory. The presented work is the result of a blast-induced brain traumatic injury study on a self-developed device. For the experiment, 15 white Wistar rats were used and were divided into 3 groups: rats of Experimental group exposed by air shock wave (26–36 кPа); Sham group (anesthesia with halothane and fixation in a horizontal position) and Intact group. The ability to learning (food reinforcement) and the spatial memory state (time to search for food, vertical locomotor activity) were studied in the complex maze during the first 5 days of the posttraumatic period. To assess the emotional state, we counted the number and observed the quality of grooming acts. All researches were conducted in compliance with modern standards for humane attitude of animals. The results of our study clearly indicate a violation of spatial memory, which was manifested in the time of searching lengthening of the feeder and in the increase of vertical locomotor activity in the rats of the experimental group, while the animals clearly remembered that they were looking for food. The analysis of grooming showed qualitative changes in the form of incomplete and prolonged acts. Such changes indicate the development of anxiety in rats with mild blast-induced traumatic brain injury. This, in turn, led to deterioration of the spatial orientation and memory formation. Thus, the consequence of a mild blast-induced traumatic brain injury in the acute period is changes in the cognitive function of the brain in the form of deterioration of spatial memory, which was aggravated by a disturbance of emotionality in the form of anxiety. At the same time, the memory regarding the presence of food was formed adequately. Keywords: explosion, central nervous system, cognitive function, memory, maze.