Computer-assisted video biomicroscopy of bulbar conjunctiva was employed to examine the sequelae of endothelial dysfunction manifested by microcirculatory bed abnormalities and microcirculation disturbances. The signs of endothelial dysfunction provoked by tobacco smoking in young adults disappeared after cessation of smoking, which resulted in pronounced widening of arterioles and capillaries as well as moderation of intravascular erythrocyte aggregation.

Relevance. In this article, the authors draw the attention of readers to the modern possibilities of using the biomicroscopy of the bulbar conjunctiva (BMBC) method in the diagnosis of microcirculatory (MC) disorders in systemic sclerosis (SS). Comparison of BMBC results of patients with SS with a control group allowed us to identify microcirculatory signs of this disease, and comparison the changes detected during nail capillaroscopy (NC) showed additional diagnostic capabilities of the BMBC method. The aim of the study was to identify new MC signs in SS using the BMBC-method, which can be further used to assess the dynamics and search for patterns with the clinical picture. Materials and methods. 48 patients with SS, the average age was 51±1.7 years were examined by BMBC, the ratio of women to men was 46:2, respectively. The control group consisted of healthy individuals without any diseases that could affect to the microcirculatory bed (MCB); the average age was 47.4±2.3 years, and the ratio of women to men was 20:10. The results showed statistically significant changes in angioarchitectonics among patients with SS compared with the control. A significant decrease in the average diameter of arterioles (14.1±0.7 μm) and capillaries (6.6±0.2 μm) was observed in the group of patients with SS compared with the control (16.6±0.6 μm, p=0.0165 and 7.3±0.2 μm, p=0.0356, respectively, for arterioles and capillaries). The decrease in capillaries during SS in four regions of the temporal section of the bulbar conjunctiva was incremental and amounted to: 15.3% in the area of the angle of the eye, 23.3% in the transitional region, 28.1% in the central and 37.9% in the perilimbal in comparison with the control. Conclusions. The BMBC-method is highly informative in the diagnosis of MC-disorders in SS. The main BMBC changes in the MC disorders caused by SS are the disturbance of MCB by the increasing tortuosity of microvessels, the contour discontinuity and the presence of local wall extensions. A peculiarity is the reduction of the capillary bed in all four regions of the temporal section of the bulbar conjunctiva with a maximum in the perilymb area.

In the young people who have ceased smoking versus the smokers, IVEA decreases and miscovascular permeability restores.

Introduction and the aim of the research. The staff of the faculty therapy department of FESMU for a long time has been studying the microvasculature (MV) by the method of bulbar conjunctiva video biomicroscopy (CAVBM) in smoking young people and the patients with ischemic heart disease. In this research we tried to find the simplified algorithm of the CAVMB and the analysis of the obtained data in current and former young smokers. We used mathematical model of logistic regression for the search of the most informative MV parameters which recovered after smoking cessation. The aim of this study was to find more significant (sensitive) parameters for analysis of the results and assessment of dynamics in the positive microcirculatory changes after smoking cessation. Material and the methods. Using a computer-assisted video biomicroscopy (CAVBM) of the bulbar conjunctiva, microcirculatory parameters were studied in generally healthy young adults who were current or former smokers (n=51). Qualitative and quantitative parameters of MV were processed by a logistic regression method. Results and their discussion. The two most significant MV parameters were identified. These parameters were found to be increased after smoking cessation and therefore can be used to determine, with a probability of 97.7%, whether an individual is a current or former smoker. These two parameters are the arteriole-to-venule ratio (AVR) and the number of capillaries in the left eye. Conclusions. We suggest a new simplified algorithm of the CAVMB with registration and analysis of only two MV quantitative parameters. We appreciate these parameters as the most objectively demonstrating the recovery of microcirculation in young subjects who quitted smoking.