We measured capillary refill time (CRT) in a convenience sample of 137 healthy newborns between 1 and 120 hours of age and 36-42 weeks gestation in the well-baby nursery of a large community hospital. CRT was measured by applying moderate pressure to the dorsum of the right hand and right foot for 5 seconds. Pressure was released and the time for complete refilling of the blanched area noted. Each infant was studied only once. We also measured ambient temperature and the skin temperature of the dorsum of the hand and foot and tested interobserver agreement. Mean CRT was 4.23 +/- 1.47 s (SD) range 1.63-8.78 s) in the hand and 4.64 +/- 1.41 s (range 2.15-9.94 s) in the foot (p = 0.0001) and did not change significantly in the first 72 hours. CRT decreased with increasing temperature. Environmental temperature, axillary temperature, and temperature of the hand and foot were all significantly and indirectly related to CRT, the strongest relationship existing between CRT and the skin temperature of the hand (r = -0.59, 95% CI -0.69, -0.47 p < 0.00001) and foot (r = -0.33, 95% CI -0.46, -0.16 p < 0.0001). With triplicate measurements, there was a statistically significant, but clinically moderate, order effect, CRT decreasing with each successive measurement (p < 0.0001). Interobserver agreement was fair, the correlation coefficient (r) ranged from 0.47 to 0.71. We conclude that CRT as measured in the hand or foot of a newborn infant in the first 5 days of life is a relatively subjective measurement with an endpoint that is not easy to define and a wide range of values in normal infants. It is influenced significantly by environmental, axillary, and skin temperatures. Since there is no accepted standard for measuring decreased perfusion in the newborn, it is impossible to document the clinical utility of CRT in this population. Further studies are necessary before CRT can be accepted as a useful measure of peripheral perfusion and circulatory status in the newborn infant.

Although a trend toward less ventilator and hospital days in the ibuprofen group was observed in this pilot study, the differences were not statistically significant. The incidence of BPD was similar in both groups. In the study group, two infants developed gastrointestinal complications and a third infant experienced reversible renal failure. The plasma ibuprofen levels were low. Further studies are needed to assess the use of ibuprofen for the prevention and/or treatment of BPD in preterm infants.

Data publishing plays a major role to establish a path between current world scenarios and next generation requirements and it is desirable to keep the individuals privacy on the released content without reducing the utility rate. Existing KC and KC i models concentrate on multiple categorical sensitive attributes. Both these models have their own merits and demerits. This paper proposes a new method named as novel KC islice model, to enhance the existing KC i approach with better utility levels and required privacy levels. The proposed model uses two rounds to publish the data. Anatomization approach is used to separate the sensitive attributes and quasi attributes. The first round uses a novel approach called as enhanced semantic l-diversity technique to bucketize the tuples and also determine the correlation of the sensitive attributes to build different sensitive tables. The second round generates multiple quasi tables by performing slicing operation on concatenated correlated quasi attributes. It concatenate the attributes of the quasi tables with the ID's of the buckets from the different sensitive tables and perform random permutations on the buckets of quasi tables. Proposed model publishes the data with more privacy and high utility levels when compared to the existing models.