Deterioration of women’s reproductive health causes an increase in the general number of oocyte donation and surrogacy programs. The formation of an allogeneic fetus in such cases affects the course of implantation and placentation, which is reflected in the increased frequency of obstetric and perinatal complications. The psychological status of these patients also has a significant impact on the course of pregnancy, childbirth and the postpartum period, which differs from that of women who are carrying their own child and/or have undergone infertility treatment. Purpose - to perform a comparative clinical and statistical analysis of somatic and reproductive history, obstetric and perinatal complications in pregnant women with an allogeneic fetus and pregnant women who were involved in in vitro fertilization (IVF) programs with their own oocytes. Materials and methods. Clinical and statistical analysis of the medical records of 200 patients, who were divided into two groups, was performed: the Group I - 150 pregnant women who were involved in IVF programs with the formation of an allogeneic fetus; the Group II (control) - 50 pregnant women who underwent IVF using the woman's own oocytes. Results. Among patients with an allogeneic fetus, a significantly lower number of various complications of somatic and reproductive anamnesis were recorded. The rates of obstetric and perinatal complications were comparable or higher as in the control group; the criteria for statistical significance of the difference were fulfilled for the indicators of gestational anemia, which was more often registered in the main group. The proportion of deliveries by caesarean section was significantly lower among pregnant women with an allogeneic fetus. The average weight of the newborn of the main group was significantly lower compared to the control. Conclusions. Despite the significantly lower frequency of detection of factors aggravating somatic and reproductive anamnesis, patients with an allogeneic fetus are characterized by comparable or higher rates of obstetric and perinatal complications, which makes it necessary to provide further investigation of the potential causes of this phenomenon, the features of the functioning of the fetoplacental complex, and the influence of the psychological status of the patients in order to improve the algorithm of pregravid preparation and antenatal surveillance. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.

The development of assisted reproductive technologies (ART) today allows many women to overcome biological barriers to motherhood. However, the use of such relatively new areas as oocyte donation and surrogacy, which result in the formation of an allogeneic fetus, is associated not only with legal but also with medical problems. Purpose - to analyze the clinical characteristics of pregnant women with an allogeneic fetus and pregnant women who were involved in ART programs with their own oocytes. Materials and methods. 120 pregnant women were examined, who were divided into the following groups: the Group I - 40 pregnant women who were involved in ART programs using foreign oocytes with the formation of an allogeneic fetus and whose management is planned to be carried out according to an improved algorithm; the Group II - 40 pregnant women who were involved in ART programs using foreign oocytes with the formation of an allogeneic fetus and whose management is planned to be carried out according to the generally accepted algorithm; the Group III - 40 pregnant women who underwent ART using the woman's own oocytes. The features of reproductive and somatic history, as well as social and demographic factors of the patient’s lives, were established. Results. Among pregnant women with an allogeneic fetus, a significantly higher proportion of women with pelvic inflammatory disease, bacterial vaginosis, cervical pathology, as well as patients with a history of surgical termination of pregnancy at the woman’s request were recorded. At the same time, the rates of registration of late menarche, endometriosis, polycystic ovary syndrome, early spontaneous abortions, as well as the following extragenital pathology: chronic arterial hypertension, diseases of the urinary system, and diabetes mellitus were significantly lower in patients of the Groups I and of the Groups II. The following social and demographic features of patients with an allogeneic fetus were noted: a smaller proportion of women with higher education, as well as those who live in their own home and are in a registered marriage compared to the control group. Conclusions. Registration of higher levels of a number of gynecological complications in pregnant women with an allogeneic fetus, as well as unfavorable social and demographic factors, requires the development of an improved management algorithm for such women, taking into account these features, which can help to reduce the rates of various obstetric and perinatal complications. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the author.

The widespread use of assisted reproductive technologies is owed to the rapid development of biomedical science. However, progress is accompanied by a steady decline in the reproductive health of the population, so the lack of knowledge today on theoretical and practical aspects remains significant. Despite the improvement of donor oocyte manipulation techniques and the outstanding success in obstetric and perinatal outcomes in cases of pregnancies with fully allogeneic fetus, the actual data on the incidence of complications of pregnancy, childbirth and postpartum period in this category of patients remain unclear. Purpose - to analyze the results of obstetric and perinatal complications in pregnant women with allogeneic fetuses, and factors that may affect them. This article summarizes the current data on obstetric and perinatal complications in pregnant women with allogeneic fetus, analyzes the biological preconditions for their occurrence, features of the fetoplacental complex in such patients, as well as the psychological status of pregnant women with allogeneic fetus, it’s potential impact on pregnancy, childbirth and the postpartum period. No conflict of interests was declared by the authors.