The full version (Appendix E1 [online]) is posted on the web pages of each of these societies. Authors include society representatives, patient advocates, an American professor of philosophy, and attorneys with experience in radiology and privacy in the United States and the European Union. Artificial intelligence (AI), defined as computers that behave in ways that previously were thought to require human intelligence, has the potential to substantially improve radiology, help patients, and decrease cost (1). Radiologists are experts at acquiring information from medical images. AI can extend this expertise, extracting even more information to make better or entirely new predictions about patients. Going forward, conclusions about images will be made by human radiologists in conjunction with intelligent and autonomous machines. Although the machines will make mistakes, they are likely to make decisions more efficiently and with more consistency than humans and in some instances will contradict human radiologists and be proven to be correct. AI will affect image interpretation, report generation, result communication, and billing practice (1,2). AI has the potential to alter professional relationships, patient engagement, knowledge hierarchy, and the labor market. Additionally, AI may exacerbate the concentration and imbalance of resources, with entities that have significant AI resources having more "radiology decision-making" capabilities. Radiologists and radiology departments will also be data, categorized and evaluated by AI models. AI will infer patterns in personal, professional, and institutional behavior. The value, ownership, use of, and access to radiology data have taken on new meanings and significance in the era of AI. AI is complex and carries potential pitfalls and inherent biases. Widespread use of AI-based intelligent and autonomous machines in radiology can increase systemic risks of harm, raise the possibility of errors with high consequences, and amplify complex ethical and societal issues.