This review provides an update on the recent gene therapies for DMD that aim to compensate for dystrophin deficiency and the related clinical trials.

Interleukin-12 (IL-12) as an antitumor and interleukin-6 (IL-6) as an inflammatory cytokine, are immunomodulatory products that play important roles in responses in cancers and inflammation. We tested the association between two polymorphisms of IL-12(1188A>C; rs3212227) and IL-6 (-174 C>G) and the risk of bladder cancer in 261 patients and 251 healthy individuals. We also investigated the possible association of these SNPs in patients with high-risk jobs and smoking habits with the incidence of bladder cancer. The genotype distributions of IL-6 (-174 C/G) genotype were similar between the cases and the control groups; however, among patients with smoking habits, the association between IL-6 gene polymorphism and incidence of bladder cancer was significant. After a control adjustment for age and sex, the following results were recorded: CC genotype (OR= 2.11, 95%CI=1.56-2.87, p=0.

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Background: This study was conducted to estimate the prevalence of mental disorders in children and adolescents in east Azerbaijan, Tabriz, Iran. Methods: A total of 1036 children and adolescents between the ages of 6 -18 were selected with cluster sampling in Tabriz city. Measurements of mental disorders were done according to the semi-structured K-SADS scale. Data were gathered by trained clinical psychologists and were analyzed by SPSS V. 16. The prevalence of mental disorders was presented with percent (95% CI) and the significance level was considered as 0.05. Results: The prevalence of any mental disorder in children and adolescents were 24.9%. The measure in boys and girls were 25.4 and 24.9, respectively. A total of 27.4% of 6 -9 years old, 23.9% of 10 -14 year olds, and 23.5% of 15 -18 year olds had suffered from at least one mental disorder. The most common disorders, respectively, were enuresis, ADHD, specific phobia, separation anxiety disorder. Panic disorder, social phobia, specific phobia, and agoraphobia occurred more in girls more than boys, while conduct disorder occurred more in boys. Conclusions:The results of this study showed that one in four children and adolescents had at least one mental disorder. Thus, considering the fact that the beginning of most mental disorders were not until adolescence years and continuation to adulthood, it is necessary that appropriate interventions were designed and executed. We must define cost effective services for early case findings and treatment of mental disorders in the regional health system.

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