Central Odontogenic Fibroma (COF) is a rare, benign neoplasm of mesenchymal origin that makes up less than 5% of odontogenic tumors commonly found in women in ratio 2.8:1. For many years there was considerable confusion concerning the criteria by which the lesion should be diagnosed and as a result, a verity of different conditions were being reported as odontogenic fibroma (OF). In this article reporting a case of COF (Epithelium Rich-type) in the maxilla radiographically presented as a well-defined radiolucent and radiopaque lesion retarding the first premolar from erupting plus reviewing the literature about COF including its variants.

Cowden syndrome is a rare cancer predisposition syndrome inherited in an autosomal-dominant fashion. The syndrome is characterized by hamartomatous polyps that affect multiple organs: skin, mucous membranes, thyroid, breast, gastrointestinal tract, endometrium and brain. It is also associated with an increased risk of developing malignancy in many tissues but especially breast, thyroid and endometrium. Thyroid tumor is ranging from benign nodule to frank malignancy. We report a case of WDT UMP in 66 years old lady who has CS.