Objective To evaluate the quantitative accuracy of clinical brain dopamine transporters (DAT) investigations utilizing 99mTc‐TRODAT‐1 single‐photon emission computed tomography (SPECT)/computed tomography (CT) in experimental and clinical settings. Materials and methods The study used an experimental phantom evaluation and a clinical dataset. Three‐dimensional‐ordered subsets expectation–maximization reconstructed the original and resampled datasets using attenuation correction, scatter correction, and resolution recovery. The reconstructed data were analyzed and reported as percentage difference, standardized uptake value reference (SUVr), and a coefficient of variation (CoV). The Taguchi method tested the impact of the three different parameters on signal‐to‐noise ratio (SNR) and SUVr, including number iteration, Poisson resampling, and phantom setup, with and without the plaster of Paris (POP). Six 99mTc‐TRODAT‐1 SPECT/CT scans were acquired in healthy subjects for verification purposes. Results The percentage activity difference between the phantom with and without POP is 20% and 5%, respectively. The SUVr reveals a 10% underestimate for both with and without POP. When it comes to the influence of Poisson resampling, the SUVr value for 75% Poisson resampling indicates 10% underestimation on both sides of the caudate and putamen area, with and without POP. When 25% of Poisson resampling is applied, the SUVr value is overestimated (±35%). In the Taguchi analysis, iteration numbers were the most dominant factor with the F‐value of 9.41 and the contribution rate of 52.66% (p < 0.05) for SNR. In comparison, F‐value of 9.1 for Poisson resampled with contribution rate of 58.91% (p < 0.05) for SUVr. Reducing counts by 25% from the original dataset resulted in a minimal bias in SUVr, compared to 50% and 75%. Conclusion The optimal absolute SPECT/CT quantification of brain DAT studies using 99mTc‐TRODAT‐1 appears achievable with at least 4i10s and SUVr as the surrogate parameter. In clinical investigations, it is possible to reduce the recommended administered dose by up to 25% while maintaining accurate measurement.

The aim of the present study is to investigate the coating effect of different amount of multi‐walled carbon nanotube on woven carbon fibre fabric. In the study, multi‐scale composites were produced using hybrid reinforcement consist of woven carbon fibre coated with multi‐walled carbon nanotubes. The coated fibres were stacked together with epoxy binder to produce composite laminates by using hand lay‐up method, followed by vacuum bagging. Measurements using zeta potential and ultraviolet‐visible analysis indicate that multi‐walled carbon nanotubes have good dispersion in water with the help of gum arabic. Multi‐walled carbon nanotubes suspension was spray coated on carbon fibre fabric at different concentrations (0.3 wt.%, 0.5 wt.%, 0.8 wt.% and 1.0 wt.%). The flexural strength and flexural modulus increased by 24 % and 34 % with addition of multi‐walled carbon nanotubes, respectively. Based on the flexural properties, 2‐ply carbon fibre /epoxy composites with 0.5 wt.% multi‐walled carbon nanotubes multiscale composite showed higher flexural strength and comparable flexural modulus compared with other composites laminates. Furthermore, the presence of multi‐walled carbon nanotubes in the carbon fibre composites reduced flammability of the composites by decreasing the burning rate of the composites containing high concentration of multi‐walled carbon nanotubes.