The diphtheria-tetanus-whole cell pertussis-Haemophilus influenzae type b vaccine under study can be safely used in the National Immunizations Program, according to the current precautions and contraindications.
Objective: To evaluate the safety of a combined diphtheria-tetanus-whole cell pertussis-Haemophilus influenzae type b vaccine used on the Brazilian National Immunizations Program, chiefly the incidence of hypotonichyporesponsive episodes.Method: Follow-up of a cohort of 21,064 infants (20,925 or 99.7% adhered to the study protocol), within 48 hours of vaccination with diphtheria-tetanus-whole cell pertussis-Haemophilus influenzae type b vaccine in health care units in the City of Rio de Janeiro, to ascertain and investigate spontaneous and solicited severe adverse events. Each child was followed-up for one dose only.
Results:The rate of hypotonic-hyporesponsive episodes was 1/1,744 doses (confirmed cases) and 1/1,495 doses (confirmed plus suspect cases). The rate of convulsions was 1/5,231 doses. No cases of apnea were detected. These results are comparable to those found in the literature with diphtheria-tetanus-whole cell pertussis vaccine.
Conclusion:The diphtheria-tetanus-whole cell pertussis-Haemophilus influenzae type b vaccine under study can be safely used in the National Immunizations Program, according to the current precautions and contraindications.J Pediatr (Rio J). 2007;83(6):523-528: Active surveillance, hypotonic-hyporesponsive episodes, DTwP/Hib vaccine, safety.
ResumoTrata-se de um relato de experiência sobre a implementação da plataforma web do SIPNI, no município do Rio de Janeiro. A parceria com o Ministério da Saúde e a Secretaria Estadual de Saúde possibilitou, de forma plena, a realização deste projeto. Foi uma experiência de muito aprendizado que proporcionou mudança no conceito de registro em vacinação, conquistando e garantindo a adesão dos profissionais das salas de vacinação, que experimentaram, a partir de sua prática, uma melhoria na qualidade dos registros dos vacinados utilizando a nova ferramenta.
Palavras-chave: Imunização, projeto piloto, sistema de informação, vacina
AbstractThis is an experience report about the implementation of the SIPNI web platform, in the city of Rio de Janeiro. The partnership with the Ministry of Health and the State Department of Health made this project fully possible. It was a very learning experience that brought about a change in the concept of registration in vaccination, conquering and guaranteeing the adhesion of the professionals of the vaccination rooms who, from their practice, experienced an improvement in the quality of the records of the vaccinated ones using the new tool.
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