Kata kunci: biakan darah, sepsis neonatorum awitan dini, sistem skoring hematologi Rodwell

Jenis Thalassemia yang paling banyak ditemukan adalah Thalassemia beta. Tercatat 10% penduduk Indonesia merupakan pembawa gen Thalassemia beta. Thalassemia beta minor sulit dideteksi karena bersifat asimtomatik sehingga peranan skrining sebagai deteksi dini sangat diperlukan. Sampai dengan saat ini di Indonesia belum dilakukan program skrining rutin Thalassemia.Tujuan penelitian ini untuk mengetahui frekuensi Thalassemia beta minor pada siswa- siswi SMA di Jatinangor. Metode Penelitan deskriptif kuantitatif, dengan teknik pengambilan data cross sectional telah dilakukan sejak bulan September sampai dengan Oktober 2015. Subyek penelitian terdiri dari siswa-siswi di 5 SMA kelas 10 dan 11 yang terregistrasi di Jatinangor. Hasil Dari seluruh siswa-siswi kelas 10 dan 11 SMA di Jatinangor, hanya ada 292 yang hadir saat penyuluhan, dan hanya 130 orang di antaranya yang bersedia mengikuti penelitian. Pada penelitian ini ditemukan 12 (9,3%) orang sebagai thalassemia beta minor. Pembahasan pada penelitian ini ditemukan 12 (9,3%) orang sebagai thalassemia beta minor. Pada penelitian lain di Banyumas didapatkan 8%.Kata kunci: Skrining,Thalassemia,Thalassemia beta minor

AbstrakLem Fibrin Komersial (LFK) sebagai biomaterial adhesif yang terbuat dari plasma beku segar donor dan bovine sudah teruji mempunyai berbagai kelebihan dibanding jahitan pada penempelan cangkok konjungtiva bulbi penderita pterigium. LFK belum tersedia di Indonesia sehingga peneliti termotivasi untuk membuat Lem Fibrin Otologus (LFO) yang terbuat langsung dari darah penderita itu sendiri. Tujuan penelitian untuk mengetahui efektivitas teknik LFO terhadap teknik jahitan pada penempelan cangkok konjungtiva bulbi. Dilakukan uji eksperimental hewan di laboratorium Bio Farma Bandung terhadap 24 kelinci New Zealand White, terbagi menjadi kelompok teknik LFO dan jahitan masing-masing 12 mata, periode September -Desember 2006. Penilaian meliputi lama operasi dalam skala menit serta attachment cangkok konjungtiva bulbi pada hari pertama dan satu minggu pascabedah. Analisis uji statistik secara Mann Whitney dan Wilcoxon rank test. Lama operasi teknik LFO secara bermakna lebih singkat dibanding jahitan (p=0,0001), sedangkan attachment jaringan cangkok pada teknik LFO lebih besar dibanding jahitan (p=0,0001). Penilaian hari pertama dan satu minggu pascabedah pada teknik LFO mempunyai nilai stabil sedangkan pada teknik jahitan terdapat perbedaan (p=0,0174). Kesimpulan penelitian ini adalah aplikasi teknik LFO lebih efektif dibanding teknik jahitan, karena lebih singkat dan attachment lebih baik serta stabil. [MKB. 2009;41(4):169-73].Kata kunci: Lem fibrin otologus, teknik jahitan, plasma beku darah, cangkok konjungtiva bulbi Bulbar Conjunctival Graft Using an Autologous Fibrin Glue in Rabbit Eyes AbstractCommercial Fibrin Glue (CFG) as a biomaterial adhesive from fresh frozen plasma donor and bovine has been tested having various superiorities compared to suturing in bulbar conjunctiva grafting of pterygium surgery. Due to CFG has not been available in Indonesia led the author to make an Autologous Fibrin Glue (AFG) directly from patient's own blood. The study aim was to investigate the effectiveness of AFG attachment. This study was an animal experimental, conducted in 24 New Zealand White rabbits divided into AFG group and suturing group of 12 rabbits each, held in Laboratory of Bio Farma, Bandung, from September to December 2006. The assessment included duration (in minute) of AFG compared to suturing techniques, also at first day and one week post grafting attachments in bulbar conjunctiva grafting. The statistical analysis used Mann-Whitney and Wilcoxon rank test. In time duration of surgical treatment, AFG technique was significantly shorter than suturing technique (p=0.0001), while first day and one week post grafting AFG attachment showed significantly greater than those of suturing attachment (p=0.0001). In the meantime, first day and one week post grafting AFG attachment was steady state, whereas in suturing technique was different (p=0.0174). In conclusion, AFG technique is more effective than

Background: Early intervention of cases with potential progression to severe disease is essential to improve survival probability in Coronavirus disease 2019 (COVID-19). Systemic inflammation plays an essential role in the process of disease aggravation. This study aimed to assess the correlation of systemic inflammatory response related biomarkers neutrophil-lymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR) on time to admission with the disease severity of inpatients with COVID-19.Methods: We performed a retrospective study using secondary data from medical records of inpatients with COVID-19 at Murni Teguh Memorial Hospital, Medan, Indonesia, from June 1 to September 30, 2020. The demographic data were collected from the medical record and the hematologic parameter from the laboratory. NLR and MLR were calculated by dividing the absolute neutrophils and monocytes counts by the absolute lymphocyte counts. The data were tabulated and analyzed by univariate and bivariate analysis with a significance level of p<0.05.Results: Study subjects consisted of 55 non-severe cases and 40 severe cases. The median NLR and MLR of severe and non-severe groups were 7.65 vs 2.92 (p<0.001) and 0.46 vs 0.25 (p=0.013). The correlation coefficients of NLR and MLR with disease severity were 0.564 (p<0.001) and 0.257 (p=0.012). The AUC of ROC analysis was 0.830 (cut-off:>4.81;p<0.001) in NLR and 0.650 (cut-off:>0.31; p=0.013) in MLR to predict the severe disease.Conclusion: NLR and MLR had a significant positive correlation with the disease severity. NLR is better than MLR in predicting severe disease in hospitalized patients with COVID-19.

Blood type phenotype incompatibility including Rhesus between donors and patients may result in cross-matching problems, triggering alloimmunization, and caused Hemolytic Transfusion Reaction (HTR). Rhesus blood type incompatibility between mother and fetus may cause Hemolytic Disease of Fetus and Newborn (HDFN). Pretransfusion phenotypic blood groups matching also reduce cost efficiently which means antibody screening is no longer needed. The purpose of the study is to find the proportion Rhesus blood type phenotypes in routine blood donors at Blood Donor Unit, Indonesian Red Cross in Bandung city, Indonesia.The study is a descriptive and observational with cross sectional design. The study was done at Blood Donor Unit, Indonesian Red Cross in Bandung city from April 2016 to September 2017. The subjects were 142 routine blood donors, blood sampling was done simultaneously with blood donation. Rhesus antigen examination of ethylenediaminetetraacetic acid (EDTA) blood was done by gel method. Subjects characteristics were male (68%) and female (32%), with the mean age was 39 years. Examination of Rhesus antigen were found antigen D(100%), antigen e(98,6%), antigen C(97,9%), antigen c(38,7%) and antigen E(31,7%). Results of Rhesus phenotypes were DCe/DCe(61,3%), DCe/DcE(29,6%), DCe/dce(7%), DcE/DcE(1,4%) and DcE/dce(0.7%). The distribution of Rhesus blood type were affected by factors such as genetics, race, ethnicity, marriage, demography, and migration. Rhesus blood phenotypes proportion in routine blood donors at Blood Donor Unit, Indonesian Red Cross in Bandung city sorted from the most are DCe/DCe, DCe/DcE, DCe/dce, DcE/DcE and DcE/dce.Keywords: blood donor, phenotype, Rhesus