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Ring closure reactions O 0130 Synthesis and Pharmacological Evaluation of Heterocycles from Benzocycloheptenones. -All synthesized compounds show some antiinflammatory activity. Compounds (V) and (IXb) show stronger antibacterial activity. -(VENKATESWARLU*, P.; VASIREDDY, N. R.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 44 (2005) 4, 783-788; Ind. Chem. Lab., Cent. Environ., JNT Univ., Hyderabad 500 072, India; Eng.) -C. Oppel 34-045

A Comparative Study on the Synthesis of 3'-Aryl-3-methyl/2, 3-Dimethylspiro[6,7,8,9-tetrahydro-5H-benzo[a]cyclohepten-5, 2'-(Tetrahydro[1,3]thiazolane)]-4'-ones Using Microwave Irradiation and ConventionalMethods. -The one-pot synthesis of new spirothiazolidine derivatives (IV) (8 examples) by consecutive condensation of cycloheptenones (I) with aromatic amines (II) and mercaptoacetic acid under both microwave irradiation and conventional, thermal conditions is described. Both methods give moderate yields, but reaction times are reduced from several hours to a few minutes using microwave irradiation. Some of the spiro-compounds obtained show good antimicrobial activity. -(VENKATESWARLU*, P.; VASIREDDY, N. R.; J.

A convenient one pot synthesis of 3 '-aryl-3-methyl/2,3-dimethylspiro[6,7,8,9-tetrahydro-5H-benzo[a]cyclohepten-5,2'-(tetrahydro[1,3]thiazolane)-4'-ones under microwave irradiation, as well as conventional methods, is described. Microwave irradiation has resulted in the reduction of time from hours to minutes. Antimicrobial activity of these compounds was studied and that some compounds gave positive results.