Introduction: Post- traumatic stress disorder (PTSD) is a psychiatric disorder which occurs after the experience of life threatening events as natural disasters, military combat, serious accidents, or violent sexual assaults. It has a severe impact on quality of life.
Aim of the work
to study the effect of single prolonged stress on the structure of hippocampus in adult male albino rats.
Materials and Methods
20 adult male albino rats were randomly divided into four groups control group (group I) and single prolonged stress group examined at day 1(group II), day 7 (group III) and day 14 (groupIV). Rats were restrained by placing them in plastic restrainers, immediately followed by 20 minutes of forced swimming in 20–24°C water. Rats were exposed to ether until general anesthesia then they were placed in their home cages. At the end of the experiment, the hippocampi were taken and processed for light microscopic study.
Results
pyramidal cells of the CA3 region of the hippocampus showed progressive degeneration with passage of time from day 1 to day 14 with decrease in thickness. Transient increase in glial fibrillary acidic protein (GFAP) expression in the astrocytes of the hippocampus was detected at day 1 followed by reduction in GFAP expression started at day seven and continued to day 14.
Conclusion
post-traumatic stress PTSD causes significant structural hippocampal neuronal damage affecting the CA3 hippocampal subfield.
Background
Nanoparticles (NPs) have unique and novel properties that lead to a diverse array of products with applications in diagnosis, drug delivery, food industry, paints, electronics, environmental cleanup, cosmetics and sunscreens. Zinc oxide nanoparticles (ZnO NPs) are one of the most widely used engineered nanoparticles in consumer products. They are utilized in many commercial products including cosmetics, paints, textiles, and personal hygiene products. The study aimed to assess the effects of zinc oxide nanoparticles administered Intranasal or intravenous on lung tissue.
Materials & methods
twenty-five male Wistar rats were divided into Group I; control group, group II (Intranasal administered group) group II (Intravenous administered group). The animals were injected with 4 mg/kg of ZnO NPs. Rat Lungs were processed for histological, immunohistochemical.
Results
ZnO NPs caused thickening of interalveolar septa. Mononuclear cells were seen infiltrating the interalveolar septa. Many dilated blood vessels exhibited focal disruption and focal thickening of their wall. Tumor necrosis factor-alpha (TNF-α) immune reactivity was significantly increased. These findings increased mainly in the intranasal administered group when compared with the intravenous group.
Conclusion
ZnO
NPs administration caused toxic effects on the histological structure of albino rat lung.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.