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Antipsychotics rank in the top five substance classes involved in human exposures. Overdose of antipsychotic medications is common. Aim of the work: to study antipsychotic drug poisoning cases that were admitted to MPCC during one year as regarding: socio demographic pattern, their clinical manifestation, investigation and outcome according to poisoning severity score (PSS). Patients and Method: Patients complaining of antipsychotic drug overdose admitted to MPCC from 1 st October 2012 to 30 th September 2013 were included. The socio-demographic and clinical data were collected from each patient in a designed clinical toxicological sheet. The studied cases were classified according to poisoning severity score. Results: The total patient's number was 60 patients. Females outnumbered males. Cases 33.3% below 10 years old were males, while females above 40 years old constituted 50.2%. Accidental poisoning was in males below age of 10 years from rural side, on the other hand 75% of females exposed to suicidal mode mainly from urban area. Regarding (PSS); most of cases were of moderate degree and the least were of severe and fatal degrees. Palpitation and abnormal movements were the commonest symptoms. Sinus tachycardia was the most prominent ECG changes seen in 20% of cases. ICU admission was indicated for 16.7% of cases. Improvement has occurred in 40% of cases, while only one case died. Conclusion and Recommendation: Significant relation was found between PSS and poison history as regard Co-ingestion and patients on antipsychotic therapy. Cases with moderate severity toxicity had palpation and abnormal movements. Acute antipsychotic overdose seldom results in death. Therefore it is recommended to improve awareness of physician about appropriate pharmacologic treatment of psychiatric problems.

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Objectives: To find out if interleukin 6 (IL-6) can be considered as a traumatic death marker or not (traumatic or non-traumatic). Background: Trauma is considered as one of public health problems worldwide causing high morbidity and mortality in developed and developing areas in the worlds. A chest trauma is any state of physical force causing injury to the chest including the ribs, heart and lungs. Cytokines are regarded as important mediators in the pathological process of inflammation. In addition, chest trauma or trauma in general has no biological marker. Role of cytokines and its relation with trauma and injuries have not been researched satisfactorily. Subject, material and methods: one hundred cadavers with chest trauma sent to Zeinhom governmental mortuary as well as non-traumatic dead cases died in Menoufia university hospital and blood samples tested for interleukin 6 level by interleukin-6 ELIZA (enzyme linked immune-sorbent assay) kits, cases divided into group I (control healthy cases), group II (that divided into two subgroups; subgroup II a include nontraumatic dead cases except cases died from myocardial infarction (MI), subgroup II b includes non-traumatic cases (died from MI) and group III (traumatic chest injuries deaths). Results: There is a highly significant difference between non-traumatic dead cases (not including MI cases) II a subgroup and traumatic dead cases III (P value < 0.001). As regarding to the mean of interleukin level it is higher in group III (58.3±20.6), it is above 3.5 folds as its value in non-traumatic dead cases (not including MI cases) II a subgroup (15.7±2.78). There is a highly significant difference between non-traumatic MI dead cases II b subgroup and traumatic dead cases III. As regarding to the mean of interleukin level, it is higher in traumatic dead cases group III (58.3±20.6) as it is above 3.5 folds as its value in non-traumatic MI dead cases II b subgroup (15.3±2.61). Conclusion: it is revealed that definitely IL6 is closely associated and increased with traumatic injury and can be considered as a trauma biomarker.