Purpose: The aim of this study was to test the signifi cant diff erences of the marginal bone loss (MBL) between screw retained versus cemented prosthesis. Materials and Methods: A comprehensive electronic searching in PubMed and Cochrane databases up to July 2015 with language restriction to English only. We include any randomized controlled trials compare between screw retained versus cemented retained implant prosthesis regarding MBL. In addition, a manual searching was performed for related journals from January 2011 to May 2015. A meta-analysis was performed on all included studies by using a random eff ect model (mean, 95% confi dence intervals [CI]) to pool the eff ect size as a heterogeneity among studies was high (P < 0.0001 and I² = 88%). Result: Initial screening and manual searching result in 199 articles from which only 4 articles compatible with our inclusion criteria. No statistical signifi cance was found between screw retained and cemented retained prosthesis regarding MBL (confi dence interval CI = 95 and P = 0.26). Conclusion:No strong evidence to support the diff erence between screw retained and cemented retained implant prosthesis in the amount of MBL as a measure for periimplantitis.