This paper introduces a general design of a silicon wire "lab on a chip" photonic biosensor for medical diagnosis application, especially for early-stage cancer diagnosis. The sensitivity of detection of the biosensors developed is at least 10-100 times more sensitive than that of current commercial biosensors. KeywordsSilicon wire evanescent field biosensor; "Lab on a chip"; cancer early-stage diagnosis; sensitivity of detection; label-free detection; real time detection; multi-analytes' parallel detection.

This paper presents the experimental achievement of a silicon-on-insulator 120 MMI splitter andsimulation evaluations of the TE-like and TM-like mode MMI splitters for parallel biosensing applications. Device fabrication technology and optical characterisation results are provided.

We investigate the impact of large temperature fluctuations on the performance of unbalanced and balanced Mach-Zehnder silicon photonic modulators and explore the trade-offs between the extinction ratio and thermal resilience.