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ObjectiveThis study aimed to investigate the association between the synaptosomal-associated protein 25 kDa (SNAP-25) genotype and performance on the continuous performance test (CPT) in Korean children with attention-deficit/hyperactivity disorder (ADHD).MethodsEighty-seven children with ADHD (mean age, 9.23±1.99 years) participated in this study. Omission errors, commission errors, reaction time, and reaction time variability on the CPT were analyzed. The single-nucleotide polymorphism (SNP) rs3746544 (1065 T>G) of SNAP-25 was genotyped to examine the association with CPT performance.ResultsWe found significantly more omission errors on the CPT among children with the TT genotype of SNAP-25 (t=2.56, p=0.012) after correcting for multiple testing.ConclusionOur results suggest the possible involvement of the SNAP-25 1065 T>G polymorphism in the inattention phenotype in children with ADHD. Further studies with more refined neuropsychological measures and much larger sample sizes are needed to confirm our findings.

According to the diversification of types of concrete structures, the quality of the concrete which is demanded also, is becoming high performance essentially. The high performance of the concrete leads using of admixtures, generally, in order to produce high strength, concrete has been used to silica fume. Silica fume is excellent mechanical properties, but unlikely to be economic. So, recently as a replacement for silica fume, metakaolin is a lot of research underway. In this study, it is used the metakaolin substitute for silica fume. For in order to prevent loss of liquidity when occurs using the admixtures, we used the silica dioxide. Therefore, concrete with the admixtures and silicon dioxide were examined the mechanical properties.

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