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It was shown earlier that the progressive growth of a transplantable T-cell lymphoma of spontaneous origin, designated as Dalton's lymphoma (DL), in a murine host is associated with an inhibition of macrophages (TAM) along with an involution of thymus. However, it remained unclear if a decline in the level of thymic peptides in DL-bearing host, due to thymic regression, has any implications in the inhibited responses of TAM. Therefore, the present investigation was under taken to study whether the TAM of DL-bearing host can be activated to tumoricidal state by peptides of thymic origin. It was observed that intraperitoneal administration of thymosin alpha 1 to DL-bearing mice resulted in activation of TAM. Such TAM were found to produce enhanced amount of interleukin-1 (IL-1), tumor necrosis factor (TNF), reactive oxygen intermediates (ROI), nitric oxide (NO) and showed an increased abilities of pinocytosis, phagocytosis, antigen presentation and tumor cytotoxicity. The TAM were found to be directly responsive to thymosin alpha1 as in vitro treatment with thymosin alpha 1 could activate TAM to tumoricidal state. Treatment of TAM with thymosin alpha 1 also enhanced their LPS responsiveness for an augmented state of activation. The findings of this study demonstrate for the first time that the TAM of a T cell lymphoma can be activated to tumoricidal state by thymosin alpha 1.

Low-velocity impact induced damage in symmetric and asymmetric laminates is analyzed. A generalized lay-up sequence is proposed for asymmetric laminate. Asymmetric laminate fabricated according to the proposed lay-up sequence have its stiffness characteristic almost identical to those of a symmetric laminates. Proposed lay-up sequence provides a laminate which have zero bending-extension coupling and behaves as quasi-isotropic laminate. A cylindrical impactor with hemispherical nose having mass 5.23 kg is impacted with a velocity of 3 ms À1 , 4 ms À1 , and 6 ms À1 . Damage pattern and energy-time relation of proposed asymmetric laminate are compared with symmetric laminate having similar stiffness matrices. Energy absorbed by proposed quasi-isotropic asymmetric and symmetric laminate is also compared with laminate of different stacking sequence proposed by various researchers. Numerical analysis is done by commercially available software LS-DYNA.

The ligand 1,4-dibenzoyl-3-thiosemicarbazide (DBtsc) forms complexes [M(DBtsc-H)(SCN)] [M = Mn(II), Co(II) or Zn(II)], [M(DBtsc-H)(SCN)(H 2 O)] [M = Ni(II) or Cu(II)], [M(DBtsc-H)Cl] [M = Co(II), Ni(II), Cu(II) or Zn(II)] and [Mn(DBtsc)Cl 2 ], which have been characterized by elemental analyses, magnetic susceptibility measurements, UV/Vis, IR, 1 H and 13 C NMR and FAB mass spectral data. Room temperature ESR spectra of the Mn(II) and Cu(II) complexes yield values, characteristic of tetrahedral and square planar complexes respectively. DBtsc and its soluble complexes have been screened against several bacteria, fungi and tumour cell lines.

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