Currently, most licensed vaccines against SARS-CoV-2 infection are approved for adults and not for children. We conducted a test negative case-control study to assess the effectiveness of Measles Containing Vaccines (MCVs) against SARS-CoV-2 infection in Pune, India, in children who were ≥1 year and <18 years of age and were tested for SARS-CoV-2 infection by Reverse transcription polymerase chain reaction (RT-PCR). The enrolled participants included 274 SARS-CoV-2 positive cases (216 vaccinated and 58 unvaccinated) along with 274 SARS-CoV-2 negative controls (265 vaccinated and 9 unvaccinated). Of the 274 cases, 180 (65.7%) were asymptomatic while 94 (34.3%) were symptomatic, all with mild severity. The number of participants with symptomatic SARS-CoV-2 infection was significantly lower in the vaccinated group compared to the unvaccinated group ( p < .0001). The unadjusted overall Vaccine Effectiveness (VE) in the vaccinated group compared to unvaccinated group was 87.4% (OR = 0.126, 95% CI of VE: 73.9–93.9) while the adjusted overall VE after adjusting for age and sex was 87.5% (OR = 0.125, 95% CI of VE: 74.2–94.0). MCVs reduced incidence of laboratory confirmed SARS-CoV-2 infection in children. Number of symptomatic cases were also lower in the vaccinated group compared to the unvaccinated group. Results of our study have provided strong preliminary evidence that MCVs have a good effectiveness against SARS-CoV-2 infection in the pediatric population, which needs to be confirmed further through prospective randomized clinical trials.

Introduction: Burn injuries are a major problem in low-income and middle-income countries. High population density, illiteracy, and poverty are the main demographic factors associated with a high risk of burn injury. Social, economic, and cultural factors interact to complicate the management, reporting, and prevention of burns. Aim: The aim of this study was to discover attributes associated with the survival of burn cases. Objectives: The objective of this study was to assess the survival of burn cases. To identify the factors associated with the survival of burn cases. Materials and Methods: This observational, cross-sectional study was conducted for a period of 1 year started from January 2013 to December 2013, in the burn ward of Government Medical College, attached to the tertiary care hospital. Results: Overall, the mean survival time was 13 days (95% confidence interval = 10–16 days). Its time was significantly different (P = 0.000). The mean survival time was significantly associated (P = 0.007) with the nature of burn. It was a maximum (18 days) in patients having burn injury at workplace. It was 13 days in males as compared to 12 days in females. The mean survival time was maximum (20 days) in burn cases occurring between 6 pm and 12 midnight and minimum (10 days) in cases between 12 pm and 6 pm. Conclusions: The mean survival time was significantly associated with nature and mode of burn but was independent of age groups, time, place of occurrence, and sex of the patient.

Background: The age of 6–23 months is the golden period in the first 1000 days of life. Insufficient quantities, frequencies, and inadequate quality of complementary feedings have a negative effect on child health and growth, especially in the first two years of life.Methods: A hospital based descriptive type of observational study was carried out in the immunization clinic. The source population were the mothers who had children in age group of 6-23 months brought to the clinic in the month of January 2021 comprise the “target population”. The sample size of 102 was calculated with 80% of power, confidence level of 95% and considering prevalence of MDD as 15.2%. Purposive sampling technique was employed for selection of study sample. Proportion of Minimum Meal Diversity and Minimum Meal Frequency was calculated and their association was assessed with anthropometric characteristics.Results: Proportion of MDD was found to be 72.5% (Figure 1) whereas Proportion of MMF was found to be 87.3 %. The proportion of MDD was significantly high among the children who had minimum meal frequency. MDD and MMF were protective against the acute malnutrition among the children.Conclusions: This study shows that consumption of a diverse diet and MMF is associated with a reduction in undernutrition among children of 6 to 23 months of age. Measures to improve the type of complementary foods given to children to meet their needs for energy and nutrients should be considered.

Background: A balanced and adequate diet is of utmost importance during pregnancy to meet the increased needs of the mother and to prevent nutritional stress. Studies have shown that a majority of pregnant women in India consume food that is deficient in protein, caloric content and other vital nutrients. In Maharashtra, 20.8% women aged 15-49 years are malnourished and 54.2% are anaemic (NFHS 5 {2019-2020} state fact sheet). Poor dietary intake is one of the common cause of micronutrient deficiency. Maternal anaemia contributes to intergenerational cycle of poor growth in the off spring.Methods: A descriptive cross-sectional study was conducted in antenatal care outpatient department (ANC-OPD) of BJGMC and SGH, Pune from January 2021 to February 2021. The 94 antenatal mothers were selected randomly. Semi structured and pretested questionnaire was used to collect the data. Percentages and frequency were used to describe continuous and categorical variables. Test of significance chi square was used with p value less than 0.05 as significant. Analysis was done using SPSS version 26.0.Results: The 91.5% subjects were aware about need of extra amount of food during pregnancy. The 95.7% agreed having extra food during pregnancy is good for health of mother as well as for baby. The 67% actually practiced adding extra food during pregnancy.Conclusions: Education level of pregnant women and socio-economic status were positively associated with nutrition knowledge. The study shows satisfactory knowledge and attitude toward nutrition and diet during pregnancy but practices toward nutrition is still lacking among the study population. Thus, significant gap is there in translating knowledge attitude in practice.

Background Government of India is introducing new and relatively costly vaccines under immunization program. Monitoring of vaccine wastage is needed to guide the program implementation and forecasting. Under pilot introduction of rotavirus vaccine in two districts both 5- and 10-doses vials were used, which was considered as an opportunity for documenting the wastage.Methods A survey conducted in two districts (Kangra, Himachal Pradesh and Pune, Maharashtra) covered 49 vaccine stores, 34 sub-centres and 34 outreach sessions collected vaccine receipt, distribution and usage data for two complete years 2016 and 2017.Results The overall wastage rates for almost all vaccines were higher in Kangra district (BCG 37.1%, DPT 32.1%, Measles 32.2%, OPV 50.8%, TT 34.1% and pentavalent 18.4%) than Pune district (BCG 35.1%, DPT 25.4%, Measles 21.7%, OPV 14.3%, TT 23.1% and pentavalent 13.2%). Wastage for pneumococcal conjugate and measles-rubella vaccines were 27% and 40.5%, respectively. With transition from 5- to 10-doses vials for rotavirus vaccine, wastage at stores levels increased in both Kangra (29% to 33.2%) and Pune (17.8% to 25.7%) districts. With transition from intramuscular to intradermal fractional inactivated polio vaccine, the wastage increased from 36.1% to 54.8% in Kangra and 18.4% to 26.9% in Pune district.Conclusions The observed vaccine wastage rates were relatively higher than program assumption for forecasting. The observed variations in the vaccine wastage indicates need for state or region based documentation and monitoring in India for appropriate programmatic action.