Background:The mammalian enzymes that form N-acylphosphatidylethanolamines (NAPEs), precursors of bioactive N-acylethanolamines, are poorly understood. Results: PLA/AT family proteins, previously known as tumor suppressors, catalyzed N-acylation of phosphatidylethanolamine, and their overexpression in animal cells remarkably increased endogenous levels of NAPEs. Conclusion: These proteins may function as NAPE-forming enzymes in vivo. Significance: Our results may contribute to a better understanding of the regulatory mechanisms of N-acylethanolamine levels.

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