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OBJECTIVE:To compare the complications of Ribbon Gauze Impregnated with soframycin nasal packing and Merocel Packing in Post Septoplasty patients. MATERIALS AND METHODS: A randomized trial was conducted in the department of Otorhinolaryngology and Head and Neck Surgery of Sri Siddhartha Medical College, Tumkur, Karnataka from July 2011-September 2014. In our study 100 patients who underwent septoplasty were divided into two groups. Group A and Group B consisting of 50 patients each. The Patients were alternately assigned into the two groups. In patients of Group A Merocel packing (size 8cm) impregnated with soframycin ointement was done. In patients of Group B Ribbon Gauze Impregnated with Soframycin packing was done. Cottle's maxillary-premaxillary septoplasty approach was employed in all the 100 patients under local anaesthesia. The complications of nasal packing like Bleeding during pack in situ, Bleeding during pack removal, Pain score during pack in-situ, Pain score during pack removal, Septal Hematoma, nasal synechia and Septal perforation were compared between the two groups. Both the groups were followed up for 8 weeks. RESULTS: In our study group A patients show statistically significant less pain score while pack was in situ and during pack removal compared with group B patients. Bleeding during pack removal and development of synechia in group A patients were statistically less compared to group B patients. None of the patients developed septal hematoma and septal perforation in both the groups. CONCLUSION: The use of Merocel nasal packing in post septoplasty patients have better compliance with respect to pain compared with conventional ribbon gauze. Although bleeding is well controlled with both Merocel and Ribbon gauze when the pack is in situ, Merocel cause less bleeding during pack removal and less nasal synechia compared to conventional ribbon gauze.