Background Psoriasis is a systemic inflammatory disorder. It is associated with increased risk of developing other chronic health diseases such cardiovascular disorders. Fetuin A is a glycoprotein that is present in blood serum. It may prevent vascular calcification by forming calciprotien particles; which are formed from their attachment with phosphate and calcium complexes. Aim The aim of this study was to measure serum Fetuin A in Psoriatic patients and correlate its level with cardiac events and risks in these patients using CT calcium (Ca) scoring. Patients and Methods 24 psoriatic patients (healthy without apparent cardiac risks to detect subclinical events if present) and 24 age and sex matched controls were tested for serum Fetuin A and underwent coronary calcium scoring by multidetector computed tomography (CT) scan. Psoriasis area and severity index (PASI) score for each patient was measured and was correlated with serum Fetuin A and CT calcium (Ca) scoring. Serum Fetuin A was compared between cases and controls and was correlated with coronary calcium score. Results There was highly statistically significant decrease in serum Fetuin A level in psoriatic group compared to control group ( P-value < .001). There was highly statistically significant negative correlation between calcium score and the level of serum Fetuin A ( P-value < .001). No statistically significant correlation was found between the serum level of Fetuin A and the psoriasis severity. Conclusion Serum Fetuin A is a simple, easy diagnostic tool to evaluate subclinical atherosclerosis in psoriatic patients

Background Psoriasis is a chronic, immune-mediated, inflammatory disease of the skin. It is a multifactorial disease with genetic background triggered by environmental factors and immunological mediators. Fetuin A is considered as a marker to detect cardiac risk. Aim of the work to evaluate Fetuin A level in psoriatic patients and its correlation to coronary artery calcification and cardiovascular risks. Methods This is a case control comparative study was conducted at Dermatology outpatient clinic, during the period from January 2019 to November 2019. The Forty eight patients who were recruited in this study were classified to two groups, Group A (cases group): included twenty four patients presented clinically with chronic generalized psoriasis randomly selected from Dermatology outpatient clinics of Ain Shams University Hospital. Group B (control group): included twenty four age and sex matched healthy volunteers who were nonsmokers, non-alcoholics and don’t suffer any systemic or organic illness. Results Our results showed no significant correlation between levels of Fetuin A and age, sex, BMI or serum levels of TG or total cholesterol among psoriatic patients. In addition, negative correlation was found between Fetuin A and calcium scoring CT scan where the median serum plasma level of Fetuin A was found to be significantly decreased in cases with plaque psoriasis with increasing calcium score, with p-value &lt; 0.001 and r = -0.928. Also, there is no significant correlation was found between levels of calcium scoring and age, sex, BMI or serum levels of TG or total cholesterol nor PASI scoring among psoriatic patients. Conclusion Fetuin A and Ca scoring CT scan appear to be a useful, simple, and noninvasive examination to investigate the presence of subclinical calcification in coronary blood vessel even in psoriatic patients who seem to be otherwise healthy.