The present work estimates the increased risk of coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 by establishing the linkage between the mortality rate in the infected cases and the air pollution, specifically Particulate Matters (PM) with aerodynamic diameters ≤ 10 µm and ≤ 2.5 µm. Data related to nine Asian cities are analyzed using statistical approaches, including the analysis of variance and regression model. The present work suggests that there exists a positive correlation between the level of air pollution of a region and the lethality related to COVID-19, indicating air pollution to be an elemental and concealed factor in aggravating the global burden of deaths related to COVID-19. Past exposures to high level of PM 2.5 over a long period, is found to significantly correlate with present COVID-19 mortality per unit reported cases (p < 0.05) compared to PM 10 , with non-significant correlation (p = 0.118). The finding of the study can help government agencies, health ministries and policymakers globally to take proactive steps by promoting immunity-boosting supplements and appropriate masks to reduce the risks associated with COVID-19 in highly polluted areas.

Covid-19 has become pandemic, spreading all over the world. Scientists and engineers are working day and night to develop a vaccine, to evolve more testing facilities, and to enhance monitoring systems. Mobile and web-based applications, based on questionnaires, have already been developed to monitor the health of individuals. Internet of Things (IoT) can be used to avoid the spreading of Covid-19. Internet of Things is an interconnection of physical devices and the Internet. Devices are not only sensel and record, but can also monitor and respond. In this paper, we have reviewed the literature available on Covid-19, monitoring techniques, and suggested an IoT based architecture, which can be used to minimize the spreading of Covid-19.

Severe acute respiratory syndrome novel coronavirus 2 (SARS-CoV-2) has caused the global pandemic as COVID-19, which is the most notorious global public health crisis in the last 100 years. SARS-CoV-2 is composed of four structural proteins and several non-structured proteins. The multi-facet nucleocapsid (N) protein is the major component of structural proteins of CoVs, However, there are no dedicated genomic, sequences and structural analyses focusing on potential roles of N protein. Hence, there is an urgent requirement of a detailed study on N protein of SARS-CoV-2. Herein, we are presenting a comprehensive study on N protein from SARS-CoV-2. We have identified seven motifs conserved in the three major domains namely N-terminal domain, linker regions and the C-terminal domains. Out of seven motifs, six motifs are conserved across different members of coronaviridae, while motif4 is specific for SARS CoVs with potential amyloidogenic properties. Additionally, we report this protein has large patches of disordered regions flanking with these seven motifs. These motifs are hubs of epitopes with 67 experimentally verified epitopes from related viruses. We report the presence of three nuclear localization signals (NLS1-NLS3 mapped to 36-41, 256-26, and 363-389 residues, respectively) and two nuclear export signals (NES1-NLS2 from 151-161 and 217-230 residues, respectively) in the N protein of SARS-CoV-2. These deciphered two Q-patches as Q-patch1 and Q-patch2, mapped in the regions of 266-306, and 361-418 residues, which potentially help in the aggregation of the viral proteins along with 219LALLLLDR226 patch. Additionally, we have identified 14 antiviral drugs potentially binding to seven motifs of N-proteins using docking-based drug discovery methods.

We are traversing the growing emerging technology paradigms in today’s advanced technological world. In this present era, the Internet of Things (IoT) is extensively used in all sectors. IoT is the ecosystem of smart devices which contains sensors, smart objects, networking, and processing units. These integrated devices provide better services to the end user. IoT is impacting our environment and is becoming one of the most popular technologies. The leading use of IoT in human life is to track activities anywhere at any time. The utmost utilities achieved by IoT applications are decision-making and monitoring for efficient and effective management. In this paper, an extensive literature review on IoT has been done using the systematic literature review (SLR) technique. The main focus areas include commercial, environmental, healthcare, industrial, and smart cities. The issues related to the IoT are also discussed in detail. The purpose of this review is to identify the major areas of applications, different popular architectures, and their challenges. The various IoT applications are compared in accordance with technical features such as quality of service and environmental evaluation. This study can be utilized by the researchers to understand the concept of IoT and provides a roadmap to develop strategies for their future research work.

In digital image different kinds of noises exist in an image and a variety of noise reduction techniques are available to perform de-noising. Selection of the de-noising algorithm depends on the types of noise. Gaussian noise, speckle noise, salt & pepper noise, shot noise are types of noises that are present in an image. The principle approach of image denoising is filtering. Available filters to de-noise an image are median filter, Gaussian filter, average filter, wiener filter and many more. A particular noise can be de-noising by specific filter but multilevel noise are challenging task for digital image processing. In this paper we propose a median filter based Wavelet transform for image de-noising. This technique is used for multilevel noise. In this paper three noise model Gaussian noise, Poisson noise and salt and pepper noise for multilevel noise have been used. In the end of paper we compare our technique with many other de-noise techniques.