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The prospective study was carried out for detecting the prevalence of HIV in sexually transmitted diseases (S.T.D) cases at Shanti infectious diseases clinic at Vadodara, Gujarat, India from January 2010 to May 2013. Out of 400 cases of sexually transmitted diseases, 317 (79.23 %) were males and 83 cases (20.75%) were females. Screening of HIV test was done by Elisa test and was confirmed by Western blot test. Amongst 400 cases 300 cases (75.00%) were in age group of 20 to 50 years, 34 cases (8,55%) wer+++e of 0 to 20 years, 66 cases 916.25%) were above 50 years. Out of 400 cases 87 cases (21.75%) were syphilis, 45 cases(11.25%) were cancroid, 73 cases (18,25%) were gonorrhea, 110 cases (27.50%) were genital herpes, 11 cases (2.75%) moll -scum contagiosum 44 cases(11,00%)genital scabies, 9 cases (2.755) cytomegalovirus infection and 21 cases (5,24%) were having lympho-granuloma venerium. Out of 400 cases of sexually transmitted diseases, 67 cases (16.76%) were HIV positive, amongst which 61 cases (91.04%) were HIV1 and remaining 6 cases (8.96%) were HIV2. Although there is plausible link between STI and HIV risk, intervention studies continue to be disappointing. This does not disprove a causal link but mechanisms of action and the design and implementation of interventions need to be better understood.

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Objective: This study was done to find out the prevalence of cardiac involvement in dengue fever in patients presented to our hospital and to find out the correlation of cardiac manifestations to warning signs and severe dengue hemorrhagic fever/dengue shock syndrome. (DHF/DSS). Methods: The one year descriptive study was undertaken at Shanti Infectious diseases clinic and Metro Hospital and Research Institute in Vadodara (Gujarat state) India. Two hundred patients aged 14 years or more with positive dengue serology were interviewed and examined. E.C.G was done for all patients and selected patients underwent Echocardiography evaluation. The data was analyzed using statistical significance test. Results: In present study 116 (58%) had warning signs and remaining 84 (42%) patients were not having warning signs. 46 patients had one warning sign and remaining 70 patients had more than 1 warning signs. 71 (35.5%) patients were having severe dengue shock syndrome (DSS). Most common warning sign was abdominal pain (52%) and persistent vomiting (45%) while hepatomegaly was the least common warning sign. The minimum pulse rate was 34 beats/minute. The most common cardiac abnormalities noted in ECG were rhythm abnormalities of which the commonest was sinus bradycardia found in 66 (33%) patients and 45 (22.5%) patients with AV block,19 cases (9.5%) with ventricular ectopic and 22 (11%) were having sinus tachycardia. Echocardiography was in selective cases showed ECG abnormality, the mean ejection fraction was 47.05 (3.8%). In 71 patients with dengue shock syndrome the mean ejection fraction was 39.63%, 57 (28.5%) patients had myocarditis with ejection fraction below 35% and global hypokinesia. Echocardiography was repeated in these 71 patients after treatment and 3 weeks of follow up and ejection fraction was 50%& global hypokinesia was also improved and ECG changes reverted to normal after 3 weeks follow up. Thus acute reversible cardiac insult was observed in dengue shock syndrome in 71 (35.5%) patients and it could be responsible for hypotension/ shock seen in these cases. Further studies are required to establish pathogenic mechanism of cardiac dysfunction in dengue shock syndrome. There was statistically significant correlation between cardiac manifestations and all warning sign except persistent vomiting. 71 (35.5%) patients with dengue shock syndrome were having mucosal bleed, fluid accumulation, respiratory distress, bradycardia with hypotension was found to have significant correlation with cardiac manifestations. Cardiac manifestation in the form of myocarditis was observed in 57 (28.5%) patients with positive correlation with severity of dengue fever defined as by W.H.O criteria. Conclusions: The most common cardiac manifestation noted wee transient rhythm abnormalities of which sinus bradycardia was seen in 66 (33%) patients, 45 (22.5%) patients had AV block and 71 Patients (35.5%) were having Dengue hemorrhagic fever/ dengue shock syndrome of which 47 (35.5%) patients had myocarditis. Patients with dengue feve...

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