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BACKGROUND: The Revised National Tuberculosis Control Programme (RNTCP), India. OBJECTIVE: To study the treatment outcomes in patients treated under RNTCP &causes of defaulted, death, failure among them. MATERIAL & METHODS: This study was conducted in Karad Tuberculosis Unit (TU), Satara District, Maharashtra. Under Karad Tuberculosis Unit there were nine PHCs, Sub District Hospital and Krishna Hospital, six Designated Microscopy Centre's (DMC), three Integrated Counseling and Testing Centre's (ICTC)-KH, SDH and Undale. All patients registered during January2008 to June 2009 i.e.806 were the study subjects. Before commencement of study permission of District Tuberculosis Officer (DTO) was taken. STUDY TYPE: Longitudinal (Prospective) Study. STUDY PLAN: Patients were interviewed using pre-tested semi structured questionnaires at their residence at the start of treatment, after completion of intensive phase and cohort was further followed up for approximately six months. RESULTS & OBSERVATIONS: Out of 233 new sputum smear positive (NSP) patients, 214 had their sputum smear negative at the end of Intensive phase (IP); hence sputum conversion rate was 91.84% in present study. We found that233newsputum smear positive cases out of which 187 were cured. Thus the cure rate was 80.2%.Out of which 506 smear negative and extra pulmonary patients 462 completed treatment hence treatment completion rate was 91.30%. Out of 233 new smear sputum positive cases, 23 died thus death rate was 9.8%, 5 patients were treatment failure thus the failure rate was 2.1 %. 12 patients defaulted the treatment thus defaulted rate was5.15%.Due to tuberculosis 22 (2.7%) patients died, 27 (3.3%) due to HIV, 17 (2.1%) defaulted due to migration, 5 (0.6%) defaulted due to addiction of alcohol, 3 (0.4%) defaulted due to not relief from symptoms, 1 (0.1%) defaulted due to adverse reaction.16 (2%) failed in due to initial heavy bacillary load. CONCLUSION: It is observed that our regimens produced decline in failure rate, default rate was near expected, death rate was little more. As cure rate was very close to RNTCP objectives, reason might be good case holding in the study. The present study revealed that deaths due to pulmonary tuberculosis even after treatment& HIV renders individuals more susceptible to death as in these study 27 deaths are due to HIV. Some people migrate to their native place or for their work and become defaulted. Default was attributed to migration to their native places in this study. Majority of cases of failure might be due to initial heavy bacillary load.

BACKGROUND Blood transfusion safety begins with healthy donors. Blood donors are deferred for multiple reasons and are not able to donate blood successfully, either permanently or temporarily. The aim of this study is to study the main causes of pre-donation deferral of potentially healthy prospective blood donors in a Tertiary care teaching hospital, Blood Bank unit.

BACKGROUND: The Revised National Tuberculosis Control Programme (RNTCP), India. OBJECTIVE: To know the socio-demographic profile of tuberculosis patients. MATERIAL & METHODS: The present longitudinal study was carried out during January2008 to June2009 on patients registered at Karad TU catering 9 PHCs, Sub District Hospital, Krishna Hospital&6DMCs with 3ICTCs.In total 806 patients were study subjects with prior permission of District Tuberculosis Officer. Patients were interviewed using semi structured questionnaires at their residence in defined time period i.e. at the start of treatment, after completion of IP. RESULT & OBSERVATIONS: Out of 806 patients 475 (58.93%) males while 331(41.06%) were females. Maximum 501 (62.15%) patients from economically productive age group i. e. 15-44 years of age. Maximum 742 (92.1%) were from Hindu community while 64 (7.9 %) were Muslims.561 (69.6%) were married, 154 (19.1%) were unmarried 18 (2.2%) were widower, 43(5.3%) were widow, 30 (3.7%) were divorced. There was 101 (12.5%) were from nuclear family, 639(79.3%) were from joint family, 66 (8.2%) were from three generation family. The maximum 694 (86.1%) patients were from lower class (i.e. class V) while 109 (13.5%) were from class IV and 3 (0.4%) patients were from class III. 239 (29.65%) patients were unemployed, 192 (23.8%) patients were working on daily wedges, and 184 (22.8%) patients had service. 186(23.1%) patients were illiterate, 215(26.7%) were studied up to primary school, 248 (30.8%) to secondary school, 134 (16.6%)to Higher secondary school, 23 (2.9%) to degree. CONCLUSION: In the present study majority of patients, 561 (69.6%) were married, 639 (79.3%) were from joint family. Maximum 694 (86.1%) were from class V(lower class).Maximum 501(62.15%) were from15-44 years of age group i.e. from economically productive age group. Prevalence of tuberculosis was higher in males than in females at all age groups. Majority of patients were literate.