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Background and Objective: Ginger has been used for a long time as a spice in food as well as pharmaceutics in a wide variety of diseases. Ginger has been shown to prevent the nausea in pregnant women. The aim of the present study was to examine the effect of hydro-alcoholic extract of ginger (HEG) on function of pituitary-gonad axis in mature male rats exposed to HEG in the prenatal period. Method: In this experimental study, 40 pregnant female rats were divided into four groups. Groups contained control, placebo (daily received 0.5 ml normal saline), and treatment groups receiving 50 mg/kg and 100 mg/kg of HEG in pregnancy period. At the end of the infancy period, males of groups were separated and 10 rats out of each group were randomly chosen in maturity. Upon the time of maturity of chosen male rats, blood samples were drawn for measurement of the levels of sex hormones in male rats. Also the number of Leydig, Sertoli, spermatogonia, spermatocytes and spermatide cells were counted. Results: Administration of HEG in groups received 50mg/kg and 100 mg/kg which resulted in a significant increase in concentration of testosterone, LH and FSH hormones in male progenies. HEG administration also significantly increased the number of Leydig and Sertoli cells, spermatogonia, spermatocytes and spermatid. Conclusion: With regard to the results of this research, consumption of HEG in the perinatal period results in increase in function of Pituitary-Gonad axis in born male adult rats.

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A 45-year-old man with bilateral blurred vision referred to toxicology department, after treatment he suffered from vision loss in left eye while his right eye was intact. Visual impairment due to methanol poisoning usually occurs bilaterally, but in our case was interestingly unilateral.