ResumenEl síndrome de Lowe (SL) es una enfermedad transmitida por herencia ligada al sexo, que afecta mayoritariamente a los hombres y muy ocasionalmente a las mujeres. El SL consiste en mutaciones en el gen OCRL1 que afectan el metabolismo del inositol fosfato, produciendo afecciones significativas de los ojos, el sistema nervioso y los riñones. En este estudio se construyó una red de interacción proteína-proteína para la enzima fosfatidilinositol 4,5-bifosfato 5-fosfatasa, en el software Cytoscape versión 3.3.0, a partir de información suministrada por las bases de datos KEGG, PubMed, BioGRID, STRING y Uniprot, donde se extrajeron 26 proteínas relacionadas con OCRL. Con base en un análisis funcional y topológico, se obtuvo que las categorías ontológicas (GO) de mayor significancia están relacionadas con el transporte mediado por vesículas y la transducción de señales medidas por pequeñas GTPasas. Por otro lado, los parámetros topológicos de la red construida fueron, coeficiente de transitividad: 0,033, diámetro: 5,0 centralización: 0,55.© 2016. Acad. Colomb. Cienc. Ex. Fis. Nat. Palabras Clave: Síndrome de Lowe; Cytoscape 3.3.0; OCRL; Bioinformática; PPIs. Network of protein-protein interaction of phosphatidylinositol 4, 5-bisphosphate 5-phosphatase, related with Lowe syndrome AbstractLowe syndrome is a disease transmitted by sex-linked inheritance. That mainly affects males, and very occasionally women. It consists of a mutation in the gene OCRL1 that affects inositol phosphate metabolism, producing significant problems on the eye, nervous system and kidneys. A network of protein-protein interaction for the enzyme phosphatidylinositol 4,5-bisphosphate 5-phosphatase in the Cytoscape software version 3.3.0 was build, from the information provided by the KEGG database, PubMed, BioGrid, STRING, Uniprot data, 26 proteins were extracted related with OCRL. Based on a functional and topological analysis, was obtained ontological categories (GO) of greater significance are related mediated transport vesicles and signal transduction steps by small GTPases. On the other hand, topological parameters of the network were built, transitivity coefficient: 0.033, diameter: 5,0 centralization: 0.55. © 2016. Acad. Colomb. Cienc. Ex. Fis. Nat. IntroducciónEl síndrome de Lowe o distrofia óculo-cerebro-renal es una enfermedad hereditaria transmitida por herencia recesiva ligada al cromosoma X, por lo que afecta en la mayoría de los casos a los hombres; las anomalías genéticas relacionadas con este síndrome se producen por deleciones, translocaciones y mutaciones stop, con una fracción más pequeña que ocurre como splicing y mutaciones sin sentido (Pirruccello & De Camilli, 2012). Ocasionalmente se han reportado algunos casos en que este síndrome se expresa en las mujeres, que por lo general, se explica por hipótesis de Lyon o por heterogeneidad genética. Sin embargo, estudios recientes han demostrado que la causa más probable de la aparición en mujeres es una translocación del segmento del cromosoma X que contiene el gen, a un aut...
Abstract-The boom in industrialization has contributed to the increase of contaminants in the environment. Chromium, in particular, a toxic metal, which in its hexavalent form is an agent that is capable of provoking damage at the cellular level. There are microorganisms with the capacity to reduce this metal to a less toxic mobile form (chromium III) as is the case of E. coli. A comparative study was conducted between some of the reductive proteins of chromium in the E. coli bacteria (YieF, NemA y NfsA), as well as the construction of a protein-protein interactive network aided by Cytoscape 3.3.0 software. This allowed the observation of variances in the characteristics related with the reduction of cromato Felicitated d by these enzymes.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.