BackgroundCardiac allograft vasculopathy (CAV) is a major limitation for long-term survival of patients undergoing heart transplantation (HT). Some immunosuppressants can reduce the risk of CAV.ObjectivesThe primary objective was to evaluate the variation in the volumetric growth of the intimal layer measured by intracoronary ultrasound (IVUS) after 1 year in patients who received basiliximab compared with that in a control group.MethodsThirteen patients treated at a single center between 2007 and 2009 were analyzed retrospectively. Evaluations were performed with IVUS, measuring the volume of a coronary segment within the first 30 days and 1 year after HT. Vasculopathy was characterized by the volume of the intima of the vessel.ResultsThirteen patients included (7 in the basiliximab group and 6 in the control group). On IVUS assessment, the control group was found to have greater vessel volume (120–185.43 mm3 vs. 127.77–131.32 mm3; p = 0.051). Intimal layer growth (i.e., CAV) was also higher in the control group (27.30–49.15 mm3 [∆80%] vs. 20.23–26.69 mm3 [∆33%]; p = 0.015). Univariate regression analysis revealed that plaque volume and prior atherosclerosis of the donor were not related to intima growth (r = 0.15, p = 0.96), whereas positive remodeling was directly proportional to the volumetric growth of the intima (r = 0.85, p < 0.001).ConclusionRoutine induction therapy with basiliximab was associated with reduced growth of the intima of the vessel during the first year after HT.

RESUMOIntrodução: O diabetes mellitus resulta em defeitos na ação e/ou secreção da insulina e possui profundo impacto na qualidade de vida. O diabetes mellitus tipo 2 (DM2) compreende 85-95% dos casos com pico de incidência aos 60 anos. As complicações crônicas podem ser evitadas ou retardadas através do bom controle glicêmico. Objetivo: Conhecer a qualidade de vida através de um questionário aplicado em diabéticos tipo 2, no distrito Portão, município de Curitiba-PR, e correlaciona-lo com o uso de insulina. Métodos: Trata-se de um estudo com delineamento transversal. A amostra consiste em 156 diabéticos tipo 2 com mais de 18 anos de idade, cadastrados nas Unidades Básicas de Saúde e Unidades de Estratégia Saúde da Família no Distrito Portão do município de Curitiba -PR. O instrumento utilizado baseia-se no questionário Diabetes Quality of Life Measures (DQOL -Brasil). As questões eram de caráter objetivo, questionando aspectos da doença, satisfação pessoal, impacto, preocupações sociais e vocacionais e preocupações relacionadas ao DM2. Resultados: 67,2% eram do sexo feminino, 58,9% tinham mais de 60 anos de idade e 46,9% eram aposentados. O tratamento com insulina associado ou não a comprimidos era utilizado por 37,2% dos pacientes. A média da hemoglobina glicada foi de 7,96% e 80,8% desconhecia sua utilidade. Foi encontrada diferença significativa (p<0,05) em todos os módulos do DQOL, mostrando maiores índices de insatisfação em usuários de insulina. Conclusão: Os pacientes com DM2 que utilizam insulina possuem piores índices de qualidade de vida quando comparados aos que não usam insulina e o uso de insulina se mostrou como fator independente na redução da qualidade de vida no distrito do Portão em Curitiba-PR.Palavras-chave: Diabetes Mellitus, DM2, Qualidade de vida, Insulina. ABSTRACTIntroduction: Diabetes mellitus is a chronic disease characterized by impaired action and/or secretion of insulin that produces a profound impact in the quality of life of its bearers. Type 2 Diabetes Mellitus (T2DM) accounts for 85-95% of all cases, achieving its peak incidence in the sixth decade. Chronic complications can be avoided or delayed through a good glycemic control. Objective: To access the quality of life of type 2 diabetics in Portão district, in the city of Curitiba, by the means of a questionnaire, and to confront this data with the use of insulin. Methods: This is a cross-sectional study. The sample consists of 156 type 2 diabetic patients over 18 years, enrolled in Basic Health Units and Units of Family Health Strategy in the District of Portão, Curitiba-PR. The instrument used in the research was based on a questionnaire entitled the Diabetes Quality of Life Measures (DQOL -Brazil). There were multiple-choice objective questions about the aspects of the disease, personal satisfaction, impact on social and vocational concerns and those related to T2DM. Results: 67,2% were female, 58,9% had more than 60 years old and 46,9% were retired. Treatment with insulin associated or not with oral drugs was used by 37,2%...

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