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To the best of our knowledge, this is the first report of an eye-threatening complication associated with amniotic membrane grafting. Caution should be exercised in utilizing amniotic membrane in patients who have undergone multiple ophthalmologic surgical procedures, which may sensitize the ocular immune system or lead to localized ischemia.

A 45-year-old man presented with floaters in his left eye and headaches for 2 months. He experienced left temporal field loss when lifting heavy objects. He took no medications and denied prior surgery, eye trauma, or pain. His best-corrected visual acuity was 20/25 OD and 20/30 OS. The only abnormalities on bilateral eye examination were 1+ levels of anterior vitreous cells and trace levels of posterior vitreous cells in the left eye, without vitreous haze, and a left retinal detachment extending from 1:30 to 10:00 o'clock, with macular involvement and without visible retinal tears. There were 360°left choroidal detachments.Optical coherence tomography showed choroidal thickening in both maculae. Fluorescein angiography (FA) of the right eye gave normal results. Figure 1A depicts the FA image of the left eye. On B-scan ultrasonography, there was a subclinical choroidal detachment superonasally in the right eye. An ultrasonographic image confirmed the detachments in the left eye (Figure 1B). The findings of a prior magnetic resonance image of the brain, chest radiographic image, and computed tomographic image of the chest were unremarkable. Test results for syphilis, tuberculosis, bartonella, and toxoplasma were negative, as were test results for inflammatory markers, quantitative serum proteins, and immunoglobulins.The patient started receiving 60 mg of oral prednisone daily. Three weeks later, his bestcorrected visual acuity worsened to 20/50 OS. A posterior sub-Tenon injection of 40 mg of triamcinolone acetonide was given, along with tapering doses of oral prednisone for 6 more weeks. There was further decline in visual acuity to 20/60 OS and worsening subretinal fluid.