The authors demonstrated a novel method to distinguish HFL from true ONL. An accurate measurement of the ONL is critical to clinical studies measuring photoreceptor layer thickness using any SD-OCT system. Recognition of the optical properties of HFL can explain reflectivity changes imaged in this layer in association with macular pathology.

Reproducibility of RNFL measurements using the Stratus OCT is excellent in normal and glaucomatous eyes. The nasal quadrant appears to be the most variable measurement. Standard RNFL and Fast RNFL scans are equally reproducible and yield comparable measurements. These findings have implications for the diagnosis of glaucoma and glaucomatous progression.

To correlate macular thickness and retinal nerve fiber layer (RNFL) thickness in normal and glaucomatous eyes using optical coherence tomography. Methods: Complete examination, automated achromatic perimetry, and optical coherence tomography of the peripapillary RNFL and macula were performed. Exclusion criteria were visual acuity of less than 20/40, diseases other than glaucoma, and unreliable automated achromatic perimetry. Macular thickness measurements were generated using 6 radial optical coherence tomographic scans (5.9 mm) centered on the fovea, and mean and quadrantic macular thickness values were calculated. Results: Fifty-nine eyes of 59 patients (29 normal and 30 glaucomatous) were enrolled (mean ± SD age, 56.7±20.3 years; range, 20-91 years). All eyes with glaucoma had associated visual field loss (mean ± SD mean defect, −8.4±5.8 dB). Mean macular thickness was significantly associated with visual field mean defect (REPRINTED) ARCH OPHTHALMOL / VOL 121, JAN 2003 WWW.ARCHOPHTHALMOL.COM

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