Summary. Introduction The article is devoted to the achievements and prospects of the development of translational medicine at the international level, the state of development, problems and prospects in Ukraine, proposals for improving the system of innovations in health care in modern conditions of martial law. The purpose is to study the development of translational medicine and the prospects for implementing its principles in Ukraine. Materials and methods. To perform the task, an analytical review of publications in the electronic databases of medical and biological publications PubMed Medline of the US National Library of Medicine (NLM), Cochrane Database of Systematic Reviews was conducted. The results. The result of a systematic literature review of the state of translational medicine in Ukraine, which was carried out, is the conviction that the need to create new services and programs that ensure close cooperation between state, commercial and non-commercial organizations of our country, greater accessibility and transparency of new data for all is ripe. Researchers working in the field of broadcasts of inventions. The creation and development of databases with various information on a large number of patients opens wide opportunities for improving the quality of preclinical and clinical trials, and at the same time requires increasing their availability for researchers around the world. It is necessary to increase the use of the potential of social media and/or messengers for the introduction of modern achievements of translational medicine into the clinical practice of our country, the medical community should receive educational programs, recommendations and support infrastructure in social networks. Conclusions. In order to form an effective scientific and educational environment, it is necessary to create a national Institute of Pharmacy and Translational Medicine. It is necessary to create and implement in the educational pharmaceutical space of Ukraine an innovative educational program aimed at training specialists and research personnel of the new generation to work in various branches of the biopharmaceutical industry. It is expedient to create biological models of the use of drugs that allow testing of dose-response effects and to build pharmacokinetic models for specific environmental conditions, which will increase the predictive power of test results during its transition to the stage of clinical trials.

Introduction. Monkey pox is an anthropozoonous disease caused by orthopoxvirus, characterized by fever, general intoxication and skin rash, in some cases it can lead to fatal consequences; an infectious disease covered by international health regulations (IHR). The causative agent of the disease is classified as a biological agent - agent of a biological weapon. Most of the monkeypox cases associated with the 2022 outbreak are in the Western Hemisphere. Purpose: study of data on etiological, pathogenetic, epidemiological aspects, modern approaches to the diagnosis, treatment and prevention of monkeypox, the state of the problem in Ukraine and the world. Materials and methods: to perform the task, a review of publications was conducted in electronic databases of medical publications PubMed Medline of the US National Library of Medicine (NLM), Cochrane Database of Systematic Reviews, CDC (Centers for Disease Control and Prevention) website of the federal agency of the Ministry of Health USA. Results: The second generation ACAM2000 and third generation JYNNEOS™ monkeypox vaccines are currently available. Both vaccines are able to create immunity against monkeypox. Post-exposure vaccination can help prevent or reduce the severity of monkeypox. ACAM2000 is a single-dose vaccinia vaccine licensed by the FDA for the prevention of smallpox. Full immunity is achieved 4 weeks after vaccination. FDA expanded access to investigational protocol allows use of ACAM2000 for monkeypox immunization during an outbreak. The immunogenicity and protective efficacy of ACAM2000 is equivalent to that of the first generation Dryvax® smallpox vaccine. Smallpox vaccine virus is used as a live attenuated virus in the smallpox vaccine. Cases of encephalitis and Guillain-Barré syndrome following smallpox vaccination show that the incidence varies not only from place to place, but also from year to year in the same place. For the purposes of containment of the outbreak, prevention to reduce the risk of transmission from person to person, immediate detection of new cases and surveillance measures are necessary. Health care workers who provide care to patients with suspected or confirmed monkeypox who work with their specimens should use standard precautions to control infection. Specimens taken from animals or humans suspected of having monkeypox should be handled in equipped laboratories by trained personnel. According to WHO recommendations, samples taken from patients should be appropriately labeled, prepared for transportation using triple packaging. To prevent the further spread of monkeypox through the animal trade, captive animals potentially infected with smallpox must be isolated from other animals and quarantined for 30 days. Conclusions: 1.The monkeypox virus, which used to be endemic to certain regions of Africa, is now a global concern, with cases increasingly being reported in regions of the Western Hemisphere. 2. In connection with the fact that transmission from person to person most often occurs through airborne droplets or through direct contact with the mucous secretions of an infected person, social distancing and contact tracing are advisable. 3. In the last 6 months, cases of monkeypox have been confirmed among middle-aged people, which can be explained by the loss of cross-immunity from the smallpox vaccine. 4. The monkeypox virus multiplies in the cytoplasm and matures, creating primary viremia. Manifestations of a severe course of monkeypox are bronchopneumonia, respiratory distress syndrome, encephalitis, chorioretinal scars on the retina, etc. To minimize the risk of complications, it is advisable to provide timely treatment. 5. Medical organizations around the world are focused on understanding how cases of monkeypox are increasingly occurring in countries in the Western Hemisphere. 6. The study of etiotropic methods of treating monkey pox is promising.

Мета. Вивчити сучасні дані про роль селену (Se) в організмі людини, методи оцінки його вмісту, шляхи профілактики та корекції селенодефіциту з позиції доказової медицини. Резюме Подані в огляді дані вказують на важливість ессенціального мікроелемента Se для забезпечення нормальної життєдіяльності людини. Відображено результати дослідження забезпечення населення селеном у різних регіонах та сучасні підходи до об'єктивної оцінки його вмісту в організмі. Наведено еталонні норми споживання селену, засновані на визначенні концентрації селенопротеїну (SePP), як найбільш об'єктивного маркера для визначення оптимального запасу Se. Доведено, що зниження або, навпаки, збільшення надходження дієтичного Se може негативно впливати на стан здоров'я, приводити до розвитку хронічних соматичних та психічних захворювань, зокрема депресії. Наведено власні дані про негативний вплив дефіциту Se на формування та несприятливий перебіг дифузного нетоксичного зобу (ДНЗ) у дітей та підлітків, які проживають в умовах легкого йододефіциту. Розглянуто шляхи профілактики та корекції селенодефіциту з позиції доказової медицини та необхідність проведення індивідуальної профілактики та корекції дефіциту Se шляхом призначення дієтичного селену, особливо у разі відсутності державних програм, що включають збагачення ґрунтів, кормів та продуктів харчування сполуками Se. Науково обґрунтовано доцільність включення препаратів Se до комплексної терапії хворих з несприятливим перебігом ДНЗ, що позитивно впливало на стан тиреоїдної системи, сомато-статевий розвиток, стан соматичного та психічного здоров'я, когнітивні функції та якість життя підлітків. Представлено результати клінічних та експериментальних досліджень, які свідчать, що включення до терапії препаратів Se у вікових дозах дозволяє  запобігти формування метаболічного синдрому та ожиріння, порушень вуглеводного обміну та тиреопатій, підвищити ефективність лікування пацієнтів з різними соматичними та психічними захворюваннями, збільшити фізичну витривалість під час інтенсивних навантажень у спортсменів.

Background. The modern medical community considers the quality of life assessment as the main and reliable tool for population-based health surveys, which are extremely relevant in the context of the persistence of the negative trend of its deterioration among school children. Most of the questionnaires are designed for children with pathological conditions, and studies of relatively healthy children are few and relate mainly to aspects of the level of physical activity and sports, and do not take into account the impact of the educational process. Aim: to determine the dynamics of changes in the quality of life associated with the health of primary school children in the learning process by quantitative and qualitative characteristics Material and methods. A prospective study was conducted over four school years through a survey using an adapted Ukrainian-language questionnaire for primary school students (624 children aged 7-11) and their parents (616 people). T-test, multiple correlations and one-way analysis of variance in the licensed software package IBM SPSS Statistics v.20.0, graph-models of correlation structures and their system analysis were used for statistical data processing. Results. The influence of gender, age, and year of study on the scale of relationships with peers, the probable increase in the 4th grade of school activity according to children, and vice versa, its decrease according to the parental version were revealed. The highest level of quality of life is set on the scale "Emotional activity", and the lowest - on school activities and relationships with adults. During the first two years of study, the main system-forming structures were emotional and physical activities, and in old age, school activity became more important. The largest qualitative differences like the links between the second and third year of the study indicated that this period of study was critical for children, and the reduction in the labilization rate indicated sufficient compensation. Conclusions. According to the study of the quality of life associated with health in the 4-year dynamics of learning, the most critical period was the transition from the second to the third grade with the preservation of a synchronized system of self-assessment of their condition. The level of physical, emotional and social functioning had certain gender and age characteristics and depended to a greater extent on the period of the educational process. The scales of school activity and socialization in their age group were especially influenced. The study found inconsistency in the perception of school life and satisfaction with communication between children and adults.

The aim of the study was to adapt a very popular in the world screening questionnaire for assessment of children psychosocial functioning. Both (parent and youth) versions of Pediatric Symptom Checklist (PSC, Y-PSC) of M. S. Jellinek, J. M. Murphy et al. were validated in Ukraine so to find out their cross-cultural universality and usefulness. The total number of study participants was 532: 281 parents fulfilled PSC-Ukr and 251 children fulfilled Y-PSC-Ukr. The sample included ordinary children, ones from families with domestic abuse and small clinical sample. Clinical interview, Kinetic Family Drawings and Sentence Completion Test were used with PSC questionnaires. Methods of classical test theory, confirmatory factor analysis and ROC-analysis were used for tests validation. Adapted versions appeared reliable and valid but had unusually low cut-offs and two-factor structure (internalizing and externalizing symptoms without separate attention deficit factor). Weak economy, military actions and upbringing peculiarities can be the reasons of unusual cut-off and factor structure of adapted tests. This test will be useful for practitioners and researchers in mental health and social work areas. PSC-Uke Y-PSC-Ukr can be recommended for use with problematic populations like children from families with domestic abuse as these methods reveal forms and degrees of children’s psychosocial dysfunction through negative growth conditions.