Introduction. There are data on the effects of dust on the respiratory system and the cardiovascular system. The main measures for preventing diseases of the circulatory system aimed to identify and eliminate risk factors. However, the prevalence of risk factors for coronary heart disease among coal mine workers with anthracosilicosis has not been sufficiently studied, determining the study's relevance. The study aimed to learn the frequency of risk factors for coronary heart disease in coal industry workers with anthracosilicosis. Materials and methods. We examined 269 miners working in conditions of dustiness exceeding the maximum permissible concentration by ten or more times: 139 miners with a previously established diagnosis of anthracosilicosis and 130 miners of the control group without dust pathology of the lungs. All of them underwent a comprehensive clinical, instrumental, and laboratory examination of the respiratory and cardiovascular systems to detect anthracosilicosis and coronary heart disease, as well as to assess its risk factors. Results. In miners with anthracosilicosis, coronary heart disease was 3.5 times more common (30.94%) than in the control group (8.46%). We have identified a high incidence of coronary heart disease in the age group of 45 and more years and with the experience of working in dust conditions of 20 and more years. In miners with anthracosilicosis combined with coronary heart disease, arterial hypertension was 1.6 times more common (58.14%) than without concomitant coronary heart disease - 35.42%. Miners with a combination of anthracosilicosis and coronary heart disease were three times more likely (20.93%) than those without coronary heart disease (6.25%) to have a metabolic syndrome. According to the Tanner index, significant risk factors for coronary heart disease were the presence of an andromorphic constitutional-morphological type and the formation of a complication of anthracosilicosis - respiratory failure. The evaluation of biochemical blood tests showed that the most significant markers of coronary heart disease risk were hyperhomocysteinemia, increased levels of C-reactive protein, fibrinogen, and soluble fibrin-monomer complexes. Conclusions. We found that the most significant risk of developing coronary heart disease in miners is 45 years and older. There are also other risk factors: work experience in harmful working conditions of 20 years or more; the presence of arterial hypertension; metabolic syndrome; andromorphic constitutional-morphological type according to the Tanner index. Risk factors are respiratory failure, hyperhomocysteinemia, hyperfibrinogenemia, increased soluble fibrin-monomer complexes, and C - reactive protein. It is necessary to consider all risks in developing programs of medical and preventive measures for employees of the coal industry.

Introduction. Emotional burnout is a condition common among workers in “helping” occupations. The syndrome of emotional burnout among workers of the main occupations of the coal industry has not been studied enough, especially in terms of its relationship with such indicators of mental health as personal, situational anxiety and alexithymia. The relationship between emotional burnout syndrome and risk factors for the development of cardiovascular diseases has not been sufficiently studied. The purpose of the study to investigate the relationship of emotional burnout syndrome with the level of personal, situational anxiety and alexithymia, and the frequency of risk factors for the development of cardiovascular diseases, such as smoking, overweight, arterial hypertension and low physical activity in coal industry workers with occupational diseases. Materials and methods. Two hundred seventy-two coal miners with occupational diseases (dust lung pathology, diseases of the musculoskeletal system, vibration disease) were examined using questionnaires by V.V. Boyko, Spielberger-Khanin, and Toronto Alexithymia Scale. According to the survey, the frequency of smoking and low physical activity was determined, the frequency of arterial hypertension and overweight was identified by the results of a clinical examination. Results. The prevalence of emotional burnout syndrome was 27.9%. A higher frequency of personal anxiety (61.1%), situational anxiety (57.1%) and alexithymia (94.7%) was revealed in emotional burnout syndrome. The frequency of smoking, arterial hypertension tended to increase with emotional burnout, the frequency of overweight, and low physical activity did not differ. Limitations. The study was limited to a sample of 272 coal miners with occupational diseases, examined using questionnaires by V.V. Boyko, Spielberger-Khanin, and Toronto Alexithymia Scale. Conclusions. Emotional burnout syndrome is associated with the development of personal and situational anxiety, alexithymia and may be a risk factor for the development of cardiovascular diseases.

Introduction. Th e high level of professional and production-related pathology among workers of the coal industry, as well as the frequent development of their combined pathology with an unfavorable prognosis determine the relevance of studying the prevalence of somatic pathology in miners with occupational diseases of the respiratory system.The aim of the study was to explore the prevalence of internal organs pathology in coal industry workers with occupational lung diseases (anthracosilicosis, chronic dust bronchitis, chronic obstructive pulmonary disease).Materials and methods. 788 store miners and shaft  sinkers with previously diagnosed occupational respiratory diseases (anthracosilicosis, chronic dust bronchitis, chronic obstructive pulmonary disease) and 161 miners, working for a long time in harmful labour conditions and having no occupational pathology (the control group) were examined.Results. It was revealed that the workers of the coal industry with occupational diseases of the respiratory system pathology of internal organs occurs more often than the workers of the control group, including: diseases of the cardiovascular system (hypertension, angina pectoris I and II functional classes), diseases of the digestive system (nonalcoholic fatty liver disease and chronic pancreatitis), kidney disease (chronic pyelonephritis), as well as a combination of several somatic diseases.Conclusions. In miners with occupational diseases of the respiratory system more oft en than in the control group, there is a pathology of the internal organs: diseases of the cardiovascular system, digestive organs, kidneys, as well as a combination of several somatic diseases. Th e data obtained should be considered during periodic medical examinations and medical examinations for the development of timely therapeutic and preventive and rehabilitation measures.

Introduction. Th e actual problem of modern occupational health is the study of the role of exogenous and endogenous factors in the development of occupational pathology of the bronchopulmonary system. То identify groups at increased risk of developing a dusty pathology of the bronchopulmonary system, it is necessary to conduct a comprehensive study of clinical and genetic factors, as well as to determine the most signifi cant diagnostic markers of the development of this pathology.The aim of the study was to study the genetic status of a set of biochemical and molecular genetic markers, as well as biochemical parameters of blood and respiratory function in coal industry workers with chronic dust bronchitis and persons of the control group.Materials and methods. 115 workers of coal mines from the South of Kuzbass aged from 39 to 58 years were examined in the Clinic of the Institute. Among them — 71 people with a previously established diagnosis of chronic dust bronchitis (the main group) and 44 people of the control group of persons working in the same sanitary conditions, but not having this pathology. A complex of clinical, biochemical and genetic methods of research was used in the study, and functional parameters of the bronchopulmonary system were evaluated. Statistical processing of the results was carried out using IBM SPSS Statistics 22 soft ware. Results. Statistically signifi cant diff erences between biochemical (increase in the concentration of ceruloplasmin and α–1antitrypsin) and immunological parameters (increase in the total number of leukocytes and ESR, increase in the concentration of IgG) in miners with chronic dust bronchitis and coal industry workers without this pathology were revealed. The dependence of the functional changes of the respiratory system with the development of professional pathology is determined. Th e persons of the main group showed a statistically signifi cant decrease in functional parameters (forced exhalation per second and lung capacity), increased respiratory failure. A predisposition to the development of dust bronchitis in the owners of the HP 1–1 genotype and resistance to the formation of this pathology in persons with the HP 2–2 genotype were found. Th e study of GSTT 1 deletion polymorphism revealed that carriers of the GSTT 1 «+» variant are most susceptible to the development of chronic dust bronchitis, and owners of the GSTT 1 variant are» resistant to its formation. Th ere was a positive аssociation with the development of dust bronchitis of the holders of the MM phenotype (MN).Conclusions. When working in similar conditions, some workers have a deviation of biochemical and immunological parameters fr om the norm, as well as a violation of the respiratory system, while others have no changes. Th e response of the body to the impact of certain external adverse factors may be due to genetic predisposition or resistance to the development of the disease.

Introduction. Clinical and experimental studies show the adverse effect of coal-rock dust not only on the bronchopulmonary, but also on the cardiovascular system. Coal mine workers have a high incidence of arterial hypertension and coronary heart disease. The key point in the prevention of the diseases of the circulatory system is the timely detection and correction of not only the main (non-occupational), but also occupational factors of cardiovascular risk. In this regard, the study of risk factors for arterial hypertension and coronary heart disease in coal mining workers is an urgent task. The study aims to explore the frequency and reveal the most significant non-occupational and occupational factors of cardiovascular risk in patients with anthracosilicosis in combination with arterial hypertension and coronary heart disease. Materials and methods. The study involved 269 coal mine workers: 139 miners with previously diagnosed anthracosilicosis and 130 miners in the control group without lung pathology. All of them underwent a comprehensive clinical, instrumental and laboratory examination to identify arterial hypertension, coronary artery disease and risk factors for the development of the diseases of the circulatory system. Results. According to the findings of the study, a significantly higher incidence of arterial hypertension and coronary heart disease was identified in the patients with anthracosilicosis compared with the miners who worked for a long time in harmful labour conditions but did not have occupational pulmonary pathology. The most significant non-occupational risk factors for arterial hypertension in the patients with anthracosilicosis were determined: age 50 years and older, the presence of fasting hyperglycemia, hyperhomocysteinemia, abdominal type of obesity, hypersthenic constitutional-morphological type according to the Rees-Eysenck index, blood group AB (IV). Occupational risk factors for the development of arterial hypertension in the patients with anthracosilicosis were also identified: work experience in hazardous working conditions of 25 years and more, the dust level in the working area exceeding the maximum permissible concentration by 10 times and more. In the patients with anthracosilicosis, the most significant risk factors for the development of coronary heart disease were: age 45 years and older, the presence of arterial hypertension, metabolic syndrome, andromorphic constitutional-morphological type according to the Tanner index, hyperhomocysteinemia, hyperfibrinogenemia, increased levels of soluble fibrin-monomer complexes and C-reactive protein. Occupational risk factors for the development of coronary heart disease in the patients with anthracosilicosis were also identified: work experience in hazardous working conditions of 20 years and more, the presence of respiratory failure (as a complication of an occupational disease). Limitations. This study is limited to a sample of workers in the main occupations of coal mines who are examined at the Research Institute for Complex Problems of Hygiene and Occupational Diseases. The age group of workers from 40 to 54 years old, with a long work experience in underground dusty conditions (more than 15 years) was studied. The study did not include persons with proven occupational diseases other than anthracosilicosis. Conclusions. The identified significant markers of cardiovascular risk can be applied to elaborate prognostic methods. Timely detection and elimination of cardiovascular risk factors as primary preventive measures should be used to reduce the level of cardiovascular incidence rate among individuals working in hazardous labour conditions. Ethics. This medical research involving a human was carried out in accordance with the ethical principles presented in the latest version of the Declaration of Helsinki by the World Medical Association.