An effective and highly regio- and diastereoselective one-pot method for the synthesis of new polynuclear dispiroheterocyclic systems with five stereogenic centers (dispiro[imidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine-6,3′-pyrrolidine-2′,3′′-indoles]) comprising pyrrolidinyloxindole and imidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine moieties has been developed. The method relies on a 1,3-dipolar cycloaddition of azomethine ylides generated in situ from isatin derivatives and sarcosine to 6-benzylideneimidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine-2,7-diones.

No abstract

Simple approach to the synthesis of 2-(4(2)- (((4,6-dialkyl-5-oxo-2-thioxohexahydroimidazo[4,5-d]imidazol-1(2H)-yl)imino)methyl)phenoxy)acetates or acetamides (new substituted thioglycolurils) based on the reaction of 5,7-dialkyl-3-thioxoperhydroimidazo[4,5-e]-1,2,4-triazine-6-ones with functionally substituted aromatic aldehydes has been developed. Synthesized thioglycolurils with acetate function can undergo further simple transformation to the corresponding acetamides.

No abstract

No abstract