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Squamous cell carcinoma (SCC) develops from keratinocytes. As per the statistical analysis, it is the second most frequent skin cancer after Basal cell carcinoma among non-melanoma skin cancers and its incidences are more than death cases . Australia has the highest incidence as compared to the rest of the world. This type of cancer is caused primarily by the exposure to the UV radiation, coming from the sun. SCC develops due to the alteration in the DNA of the squamous cells present in the outer skin layer. In this carcinoma, an early stage shows replacement of normal epithelial cells by atypical squamous cells throughout the epidermis, resulting in abnormal growth. Immunotherapy has shown to be a promising development in the past few years. The recent activities have increased our understanding of the tumour microenvironment, various immunotherapeutic modalities or combination therapy (like chemotherapy with immunotherapy). The complete perspective of the immunotherapy treatment has not been realized yet. Additionally, the effects of such modalities in combination with immunotherapy in cancer patients are still exploratory phase.

Background: Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders in children. It is usually first diagnosed in childhood and often lasts into adulthood. Children with ADHD will have trouble paying attention, controlling impulsive behaviors, or be overly active. The hallmarks are hyperactivity, impulsivity, and inattention that are beyond reasonable developmental expectations for a child's age. The science behind Brillia is based on a new way to combine homeopathy and antibody science. The active ingredient of Brillia, Lapine S-100 immune globulin, is produced using antibodies to the brainspecific S-100 protein (S-100B). This protein is an essential regulator of many different intracellular and extracellular brain processes, e.g., various enzyme activities, calcium homeostasis, communication between neurons, etc. Thus, the clinical study of the efficacy of Brillia for Children for the treatment of anxiety disorders, disturbances of behavior, and attention, accompanied by increased excitability, irritability, and hyperactivity, are very important and promising. To determine the efficacy of Brillia for Children for the treatment of anxiety disorders, disturbances of behavior, and attention, accompanied by increased excitability, irritability, and hyperactivity in children, two clinical studies were carried out.Methods: A double-blind, randomized placebo-controlled study of Brillia evaluating clinical efficacy and safety for children with attention deficit hyperactivity disorder was conducted. Prior to inclusion in the study, the patients or their legal guardians were provided with information about the study and signed an informed consent form. Patient information collected during the study is strictly confidential.

Pancreatic cancer is an aggressive and highly lethal form of pancreatic malignancy which is the fourth leading cause of cancer-related deaths in men and women in the USA. According to the American Cancer Society in 2014, it was estimated that about 46,420 people (23,530 men and 22,890 women) were diagnosed of pancreatic cancer. Additionally, in the same year about 39,590 people (20,170 men and 19,420 women) died of pancreatic cancer. It is highly observed men over women and also common with increasing age. The availability of new technology in diagnosis helps in the early detection of the pancreatic cancer. These technologies will serve as the primary requirement for management of disease. The exact cause of pancreatic cancer is not known, several risk factors had been indicated leading to pancreatic cancer. Immunotherapy has been a promising development in the past few years. The recent activities have increased the understanding of the tumor microenvironment, various immunotherapeutic modalities or combination therapy (such as chemotherapy with immunotherapy) had been applied in clinical trial. Additionally, the effects of such modalities in combination with immunotherapy in cancer patients are in still exploratory phase.

Penis cancer is when the malignant cells appear in the tissues of the penis. Approximately 95% of penile cancers are squamous cell carcinoma. Othertypes; of penis cancer like melanoma, small cell carcinoma, Merkel cell carcinoma are usually rare. 1 The penis cancer is also very rare in Europe and North America. In the United States, penis cancer generally occurs in less than 1 man in 100,000 and accounts for less than 1% of cancer in men. However, penis cancer is much more common in some regions of South America, Africa, and Asia, where it holds for up to 10% of cancers in men. 2 According to the National Cancer Institute, in the year 2014 in United States, 1,640 new cases were estimated. Additionally, in the same year, 320 death cases were also estimated. 3 As per the statistical analysis, the agestandardized incidence of penis cancer is much higher in non-Western world. It signifies 10-20% of cancerous disease in men, ranging from 0.7 to 3 per 100,000 persons in India to 8.3 per 100,000 men in Brazil, and even higher in Uganda, where it is usually diagnosed. The penis cancer is a very rare cancer among all the male cancers, with higher incidences observed in between the age of 75-84 years. 2,4 Etiology/Predisposing FactorsGenerally, penis cancer occurs in the uncircumcised men. Circumcision is the elimination of the foreskin,and may decrease the chances of penis cancer. 5 The different types of penis cancer are as follows: 5 a. Epidermoid/squamous cell carcinoma: About 95% of the penile cancers are squamous cell or epidermoid carcinomas. The epidermoid carcinoma can initiate anywhere on the penis; though, it normally develops on or under the foreskin.b. Basal cell carcinoma: Below the squamous cells in the lower epidermis, are round cells, known as basal cells and occasionally, these can transform into malignancy. It is a type of non-melanoma skin cancer, which represents less than 2% of penis cancer.c. Melanoma: Although, this type is the rarest subtype of penile cancer, it is the one with the worst prognosis.d. Sarcoma: Sarcoma accounts for about 1% of penis cancer. These are the cancers that develop in connective tissues, such as fat, muscles, and blood vessels.