Background: Allergic rhinitis is one of the most common and most prevalent ailments, familiar to all with an equal distribution more or less throughout the world, rather without any exception to the developed and under developed countries. Repeated attack and improper management of the disease leads to many complications like recurrent sinusitis, nasal polyps, serous otitis media, orthodontic problems etc. Objective: To evaluate the role of Ayurvedic Formulations in the management of Allergic rhinitisMaterials and methods: The study was executed as on open label, multicentric, prospective clinical study executed at (CARI, New Delhi and CARI, Mumbai). Sixty participants aged between 18 and 65 years, having the symptoms of Allergic rhinitis were enrolled in the study as per the inclusion and exclusion criteria. The intervention given to the participants were Ayush VPR (3.5gm) in the form of Churna (powder) twice a day with honey and Ghrita (clarified butter) after food, Shirishadi Kwath (20 ml) twice a day, orally in empty stomach and Nasya (intranasal drug administration) with Anutaila for 07 days for two consecutive cycles with the interval of seven days. The assessment was done every week. Total duration of intervention was 28 days followed by follow up of 28 days on the interval of 14 days. The primary outcome was assessed by seeing the change in the CARAT (Control of Allergic Rhinitis and Asthma Test) scorewith Mauchly’s test of sphericity (b).Results: The mean CARAT score was found to reduce subsequently from baseline to 7th, 14th, 21st and 28th day. A significant improvement in the mean total CARAT score (p < 0.001) was observed after 28th day of treatment and also at the end of the 56th day in comparison to baseline (Mauchly's Test of Sphericity (b) Measure) Conclusion: The Ayurvedic formulations, Shirishadi Kwath, Ayush VPR and Anutaila are safe and significantly reduced rhinorrhea, nasal itching, Sneezing fits, nasal congestion, and nasal obstruction. The present study reveals that Ayurvedic treatment according to the line of treatment of Vataja Pratishyaya provided highly significant relief from Allergic rhinitis.

Background: The purpose of our study was to compare the effect of vacuum assisted closure (VAC) therapy and conventional dressings in patients with open wounds due to necrotizing fasciitis (NF) on the basis of healing rate, infection control, frequency of dressing and pain score.Methods: The study evaluated 50 patients admitted with NF requiring surgery over a period      of 18 months.  The patients were randomized to two groups. In group A patients, the wounds were managed with conventional dressings and in group B patients, negative pressure wound therapy (NPWT) was applied. Serial assessment of both groups was done for four weeks. The parameters including size of wound, wound bed, granulation tissue formation, color, amount and odor of exudate, edema, frequency of dressing, re-debridement and pain were monitored and analysed.Results: In our study, patients with NF wounds who underwent VAC therapy had earlier granulation tissue formation, resolution of infection and readiness for skin grafting. The frequency of dressing, requirement of re-debridement, resolution of edema, odor, skin maceration, inflammation around wound and pain significantly reduced in group B (VAC) when compared to conventional dressing group.Conclusions: When compared to the conventional dressing on NF wound, application of VAC helped in early appearance of granulation tissue, significant reduction of inflammation, wound odor, exudate, need for re-debridement, frequency of dressing and pain. Thus, VAC dressing can be considered as a better option in the management of NF wounds.