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The purpose of this study is to extract natural hydroxyapatite (HAP) from cow bone. The hydrothermal method followed by calcination treatment at different temperatures is used in this current research. Cow bone has the potential for producing hydroxyapatite, a chief component present in bone and teeth of vertebrates. HAP is an excellent material used in bone restoration and tissue regeneration. Characterizations of the cow bone natural HAP powder were done by X-ray diffraction (XRD) and Thermogravimetric analysis (TGA). TGA data revealed that biological apatite is thermally stable at 1100°C. XRD data showed that the extracted HAP is, highly crystalline and hexagonal crystal structure having a crystallite size in the range of 10-83 nm. The extracted HAP material is found to be thermally stable up to 1300°C.

Composites material were developed to acquire the desired material properties for biomedical applications in the recovery of defect bone by using Mg-doped HA/SA. Hydroxyapatite (HA) is the major constituent and essential component in bone and teeth. The stability of Mg doped HA/SA is influenced by starting precursor powders, preparation condition and method of preparing the samples for implant materials. The precipitation method was employed to prepare Mg-doped HA/SA powders by varying the composition of Mg at temperature 1300 C. The influence of Mg-doped HA/SA on phase composition, chemical structure and a functional group at various weight percentages (0.5wt%-1.5wt %) were accomplished through X-ray diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR) analyses. Based on the XRD and FTIR analyses, there is the presence of different peaks intensity and adsorption bands which indicates the shifted of peaks due to the doping process and a chemical interaction were observed between the inorganic and organic phase. Furthermore, the transformation of β-TCP due to increase in sintering temperatures are caused by the presence of magnesium ions. The OH stretching bands of HA/SA are trace by FTIR that identified the decomposition of Mg-doped HA/SA.

In the current paper, nanobiocomposite consisting of polylactic acid (biodegradable) (PLA) and nanohydroxyapatite (bioactive) (n-HAP) extracted from bovine bone was fabricated through melt mixing and injection moulding technique for biomedical applications. Partially biogenic nanohydroxyapatite was obtained from bovine bone by hydrothermal method and calcination treatment without using of any chemicals/solvents. Physicomechanical properties of neat-PLA and PLA/n-HAP nanobiocomposite were evaluated using X-ray diffraction (XRD), universal testing machine (UTM) and scanning electron microscopy (SEM). XRD result showed that the intensity of n-HAP peaks increased in the nanobiocomposite as n-HAP-900 loading increased. Tensile strength decreased with increasing the n-HAP-900 loading from 56.78 to 48.25 MPa due to poor interfacial adhesion between neat-PLA and n-HAP. PLA/n-HAP with 1% loading exhibits tensile strength potential for bone implant application and can be promising biomedical materials for orthopedic applications.

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