No abstract

e451 lower thoracic spinal cord with hyperintense signal in T2 left hemicord. The major capsid protein (VP1) of the Sabin virus T1 isolated in feces showed a 96.5% genetic similarity to Sabin 1 vaccine strain (a 3.5% genetic divergence in this region). Conclusion:The occurrence of iVDPVs appears to be very rare; the majority of patients stopped excretion of the virus after a certain period or have died. The overriding factor for the emergence of all VDPVs is the same as for WPV circulation, i.e., low routine OPV coverage rates in children. Thus, a community can become susceptible to the emergence of all types of VDPV producing an impact in the public health of the population. New polio vaccination strategies should be considered to avoid future VDPV cases and to be aligned WHO endgame strategies.