International and national crises often highlight inequalities in the labor market that disproportionately affect individuals from marginalized backgrounds. The COVID-19 pandemic, and the resulting changes in society due to social distancing measures, has showcased inequities in access to decent work and experiences of discrimination resulting in many of the vulnerable populations in the United States experiencing a much harsher impact on economic and work-related factors. The purpose of this essay is to describe how the COVID-19 pandemic may differentially affect workers of color, individuals from low-income backgrounds, and women in complex ways. First, this essay will discuss disproportionate representation of workers from low-income and racial/ethnic minority backgrounds in sectors most affected by COVID-19. Second, it will discuss the lack of decent work for low-income workers who perform "essential" tasks. Third, this essay will highlight economic and work-related implications of increased discrimination Asian Americans are experiencing in society. Finally, role conflict and stress for women who are managing additional unpaid work, including caretaking responsibilities, while needing to continue to engage in paid work will be examined. A research agenda will be set forth throughout the essay, calling for vocational psychologists to engage in research that fully examines how the COVID-19 pandemic is affecting vulnerable communities.On March 31, 2020, during the rise of the COVID-19 pandemic in the United States, Andrew Cuomo, the governor of one of the hardest hit states, New York, wrote on Twitter that the coronavirus is the "great equalizer" (Cuomo, 2020), reflecting the sentiment that the virus was capable of sickening anyone regardless of age, social status, race/ethnicity, or gender. Governor Cuomo's tweet was well meaning in nature but did not accurately reflect the differential impact of the virus on historically marginalized groups in the United States. International and national crises, including pandemics, often highlight inequalities that may have been unseen or hidden prior to the crisis. COVID-19, and the resulting changes in society due to social distancing measures, have showcased inequities in access to decent work and in experiencing discrimination resulting in many of our most vulnerable populations in the United States (e.g., racial/ethnic minorities, individuals from low socioeconomic backgrounds, and women) experiencing a much harsher impact on work-related and economic factors.Racial, gender, and social class disparities have been well documented in educational and work opportunities for decades (Flores, Martinez, McGillen, & Milord, 2019). For individuals from vulnerable or marginalized backgrounds, educational systems, labor markets, and workplace environments often perpetuate systems of oppression, power, and privilege, resulting in them experiencing marginalization and discrimination within these systems and obtaining poorer educational and vocational outcomes (Flores et al., 2019)....