Background : Hypertension is a major risk factor for early death and cardiovascular disease (CVD), which causes at least 1.1 million deaths per year in the world. Hypertension is also called The Silent Killer because it is often found without symptoms, which if left untreated and treated will cause complications such as stroke, heart and blood vessel disease, kidney disorders and others which can ultimately lead to disability or death. Endothelial dysfunction indirectly affects platelet dysfunction which can be assessed based on platelet index and platelet lymphocyte ratio. 2,6,7Method :170 Patients with hypertension are grouped into hypertensive stage groups 1, 2 and 3. Platelet index (MPV, PDW and PCT) and lymphocyte platelet ratio are calculated based on the results of routine blood tests. Data distribution was tested by Kolmogrov-Smirnov and analyzed with the corresponding data test.Results:Platelet index namely MPV in hypertensive patients was significantly different in each degree of hypertension, grade 1 (8.92 ± 1.23), degree 2 (8.99 ± 1.63) and degree 3 (11.2 ± 4.29) with a p value = 0.003. There is a weak correlation between MPV and serum creatinine ureum levels. However, PDW and RTL values only correlate with creatinine.Conclusion:There are differences in the value of MPV in patients with hypertension of various degrees. There is a correlation between the values of MPV, PDW and RTL and creatinine which indicate inflammation of the glomerulus.

ANALYSIS PLATELET INDICES IN PATIENT TYPE 2 DIABETES MELLITUS WITH VASCULAR COMPLICATION      Nelly1, Suci Aprianti2 ,Darmawaty ER31Medical Doctor Specialist Education Program of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo hospital, Makassar2Departement of Clinical Pathology, Faculty of Medicine, Hasanuddin University3Departement of Clinical Pathology, Faculty of Medicine, Hasanuddin University /Dr. Wahidin Sudirohusodo Hospital, Makassar ABSTRACT Introduction :Type 2 Diabetes Mellitus(T2DM) is an endocrin disease that is marked by hyperglycemic condition due to a decrease increase in insulin secretion and insulin resistance or both. Indonesia is the 7th country with the highest incidence of diabetes mellitus in the world. Progression of the disease is slow and cause vascular endothelial damage. The increase  of platelet indices is suspected to be an indications   of vascular complicationsObjective :To evaluate the  platelet indices in diabetics patients with complication and correlate these indices with GDP and HbA1c. Materials and methods :We analyzed platelet indices and biochemical data of patients seen in outpatients by clinicans of  wahidin soedirohusodo hospitals. 120 patients with type 2 diabetes mellitus were included with 64 patients vascular complication and 56 patients without complication.Result :We observed an increase in mean platelet volume (MPV): 9,96 + 1.99vs 8.87 + 1.35(p-value: 0,001) ;in platelet distribution width (PDW): 15.29 + 3.45 vs 12.36 + 2.819(p-value: 0,000; without increase  plateletcrit (PCT); 0.28 + 0.14 vs 0.25 + 0.12 (p-value: 0.168). we observed  a correlation between FBG with PDW (P=0.044).Conclusion :The study findings point to the significant differences in platelet indices (MPV and PDW) in patients with T2DM with complication and without complication, suggesting the presence of platelet in diabetics type 2 patients more reactive and aggregatable  in this group of individuals. These suggest that platelet evaluation may be useful in the early detection of long term complication in diabetics patients.Keyword :T2DM, platelet indices, complication vascular