Objective: To identify hemolysis, icterus, lipemia (HIL) indices measurement on four clinical chemistry analyzers: Abbott Architect C8000 (AA), Roche Cobas C501 (RC), Beckman Coulter AU5800 (BC), Siemens Advia 1800 (SA). Subject and method: Plasma of patients were examined at 108 Military Central Hospital (108 MCH) from 12/2020 to 04/2021, comprising of 240ml normal plasma sample, 30ml artificial hemolyzed plasma for H index, 30ml icteric plasma with 360μmol/L total bilirubin, 30ml plasma with 1g/L of Intralipid 20% for lipemia. A cross-sectional study was conducted to compare results of HIL indices on 4 analyzers Abbott Architect C8000 (AA), Roche Cobas c501 (RC), Beckman Coulter AU5800 (BC), Siemens Advia 1800 (SA). Result: The agreement of H index among 4 instruments was good, and values of I index on the AA, SA, RC were absolutely suitable (kappa 0.75 - 1.0). Nevertheless, the comparability between results of I index on the BC and 3 others platforms was mediate (kappa 0.53 - 0.55) while I index on the RC, SA, AA was extremely suitable (kappa 1.0). Even though, the agreement of L index between BC and SA was not acceptable (kappa < 0.2), it was comparable on the remaining analyzers (kappa 0.55 - 0.933). Conclusion: There was comparability of HIL indices among 4 analyzers except L index between the BC and SA. Specifically, the results of all HIL indices on the SA, RC, AA analyzers were high agreement.