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Large urban areas are currently facing the problem of increasingly serious air pollution, which greatly affects human health and economic development. The sources of air pollution are mainly from industrial activities, transportation and human activities. Air pollutants data can be monitored and extracted from remote sensing images. This research aims to assess the level of NO2 and SO2 pollution in the air from data collected by OMI (Ozone Monitoring Instrument) on AURA satellite of A-Train group. Pollution levels of NO2 and SO2 will be calculated, assessed. Then, a map illustrating the trend of NO2 and SO2 in Ho Chi Minh City during the period of 2015-2019 will be made. The results of the study showed that NO2 concentration varies significantly with the seasons, relatively high in the dry season reaching 70 (μg/m3) and decreasing in the rainy season. The concentration of SO2 varies relatively evenly in the area and increases in industrial areas with concentrations ranging from 0.1 to 1.37 mg/m3. Therefore, it is necessary to speed up the rapid monitoring of air pollution in urban areas and large cities in order to get accurate, fast and timely air pollution information to have more appropriate and effective mitigation and prevention measures.