In the Red River Delta, the concentrations of Arsenic in groundwater of alluvial dominated systems are very high, exceeding the WHO’s permissible. The correlation between the Arsenic concentrations in groundwater and the age of Holocene sediment as a key controlling groundwater Arsenic concentration in the Red River delta has been investigated. The evolution of sediments in the Holocene is closely related to paleo-riverbed migration in the past. A combination of methods is implemented including remote sensing, multi-electrode profiling (MEP), gamma-logging, drilling, soil sample and groundwater modeling. The resul has identified the shape, sediment compositions and location of the six paleo-riverbed periods. The age of the paleo-riverbed is determined by drilling, soil sampling and optically stimulated luminescence (OSL) in the laboratory. The oldest sediments is 5.9±0.4 ka BP in Phung Thuong near the mountain, the youngest one is from 0.4÷0.6 ka BP in H-transect near the Red River and the rest of the other is around 3.5 ka BP. The modeling results by using MODFLOW and MT3D show that the dynamics of paleo-riverbeds controlling Arsenic mobilization in groundwater in the Red River Delta. When the river moved to another position, the current river position at that time was filled with younger sediments and became paleo-riverbed formation with reducing conditions, Arsenic content which was adsorbed in the previous stage then released into groundwater. Therefore, Arsenic concentration in groundwater of young Holocene sediments is higher than in older ones which elucidates that paleo-riverbed migration controls on Arsenic mobilization in groundwater in the study area.

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Chlorpheniramine (chlorphenamine, CPAM) is a racemic antihistaminic H1 drug containing two enantiomers. The aim of this study was to assess the bioequivalence of two formulations (reference and Vietnamese-tested formulation) of racemic chlorpheniramine combined with phenylpropanolamine in an open-labeled, randomized, crossover two-period study, after administration of 8 mg of racemic chlorpheniramine in 12 healthy Vietnamese subjects. First, dissolution of both formulations was tested in vitro according to USP requirements. Then the 12 subjects received both formulations after an overnight fast and a 7-day wash-out period. Plasma samples were collected up to 168 h. Plasma concentrations of total chlorpheniramine and its individual enantiomers were determined with a validated chiral HPLC method and pharmacokinetic parameters were estimated using model-independent analysis. For the reference formulation, Cmax and AUC values were higher for (+)S-chlorpheniramine ((+)S-CPAM) compared to (-)R-chlorpheniramine ((-)R-CPAM) (13.3 vs. 6.8 ng/ml and 409 vs. 222 ng/ml/h, respectively) while Clt/F and Vd/F were lower (9.8 vs. 17.6 l/h and 321 vs. 627 l, respectively). No difference was observed for Tmax, t(1/2), and MRT. Pharmacokinetic parameters were similar for the reference and the Vietnamese-tested formulation. Bioequivalence was assessed by Schuirmann test, as recommended by the current FDA and European Community criteria. Dissolution tests showed that both formulations were equivalent. A nonstereospecific, but not a stereospecific, approach indicated bioequivalence between the formulations.

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The effect of machining parameters on the surface roughness in dry-turning Ti6Al4V alloy using an experimental design method was investigated. A mathematical equation based on the response surface methodology was established to fully understand the influence of machining parameters (cutting speed, feed rate, and depth of cut) on the surface roughness. A set of experiments based on a three-level statistical full factorial design of the experimental method was performed to collect the mean of surface roughness data. The model of R2=0.9656 shows a good correlation between the experimental results and predicted values. The analysis results from the model revealed that the feed rate is the dominant factor affecting surface roughness, followed by cutting speed, and depth of cut. The surface roughness was minimized when the feed rate and depth of cut are set to the lowest, and the cutting speed was set to the highest level. Verification of the experimental results indicated that the surface roughness of 0.832 µm at cutting speed of 200 m/min, feed rate of 0.1 mm/rev, and depth of cut of 0.1 mm were achieved under the optimal conditions