Traditional plant used for treatment of diabetes has shown a surging interest in the last few decades. The purpose of this study is to evaluate the effect of 70% (v/v) ethanolic extracts of several untested herbal sources, such as papaya leaves, papaya seeds, fig fruits, fruits of Xanthium strumarium, and leaves of Gomphrena celosioides on blood glucose levels of streptozocin (STZ)-induced type 2 diabetic mice. The results proved that diabetic mice treated with the extracts of papaya seeds, papaya leaves and fig fruits showed significant reduction of the blood glucose levels at a dose of 500 mg/kg body weight when compared to control. Antihyperglycemic activity of the papaya leaves (52.38%) and papaya seeds extracts (53.16%) were significantly higher than the extract of fig fruits (27.90%). Furthermore, the α-amylase inhibition assay showed that the extracts of papaya seeds (58,63 ± 0,06 μg/ml), papaya leaves (34,28 ± 0,06 μg/mL) and fig fruits (79,24 ± 0,83 μg/mL) exhibited 50% α-amylase inhibition activity at the mentioned concentrations. The α-glucosidase IC50 of the extracts of the papaya seeds, papaya leaves and fig fruits were found to be 24.36 ± 0,29, 27,60 ± 0,43 and 106,44 ± 1,54 respectively. The results of the study indicate the potential of these extracts to manage hyperglycemia. The histopathological study of the papaya seeds extract has shown to ameliorate the streptozocin-induced histological damage of islets of Langerhans in the pancreas.

Some extracts of medicinal plants have been proven to be beneficial in treating a number of diseases for centuries such as treating diabetes, antioxidant, anti-inflammatory, antibacterial, etc. This study aimed to evaluate the effect of extracts from several herbal plants, such as Gymnema sylvestre, Stevia rebaudiana, Cinnamomum cassia, Zea may, Ocimum basilicumon on blood glucose level in streptozotocin (STZ) induced diabetic mice and to offer scientific proofs for the identified antihyperglycemic effect by investigating on mechanisms of the most effective extract. The results proved that diabetic mice treated with 70% ethanol extracts of Gymnema sylvestre leaves and Stevia rebaudiana leaves showed significant reduction of the blood glucose levels at a dose of 500 mg/kg body weight when compared to control (P < 0.05). Antihyperglycemic activity of Gymnema sylvestre (57.68%) and Stevia rebaudiana extracts (54.93%) was significantly higher than those of other extracts. The inhibition of α-amylase and α-glucosidase activity of Gymnema sylvestreand, Stevia rebaudiana extracts were carried out in vitro. The results demonstrated that these Gymnema sylvestre and Stevia rebaudiana extracts were able to strongly inhibit the activity of α-glucosidase and α-amylase, with the IC 50 values lower than the recently published values around the world about 2−5 times. Using 1,1-diphenyl-2picrylhydrazyl (DPPH) assay showed that Gymnema sylvestre and Stevia rebaudiana extracts exhibited relatively low antioxidant activity with the concentration of a sample required for 50% scavenging of the DPPH free radical of 115.88  1.16 µg/mL and 160.27  2.01 µg/mL compared to vitamin C (49.16  1.26 µg/mL). , 2019. Study of antihyperglycaemic activity in streptozotocin induced diabetic mice and antioxidant activities of medicinal plant extracts. Tap chi Sinh hoc, 41(2): 119-128. https://doi.1 Trường Đại học Bách khoa, Đại học Đà Nẵng, Việt Nam 2 Viện Nghiên cứu và Đào tạo Việt -Anh, Đại học Đà Nẵng, Việt Nam 3 Viện Hoá học, Viện Hàn lâm Khoa học và Công nghệ Việt Nam, Việt Nam Ngày nhận bài 24-4-2019, ngày chấp nhận 25-6-2019 TÓM TẮTMột số chiết xuất của cây thuốc đã được chứng minh tiềm năng có lợi trong điều trị một số bệnh trong nhiều thế kỷ như điều trị bệnh đái tháo đường (ĐTĐ), khả năng chống oxy hóa, kháng viêm, kháng khuẩn,… Nghiên cứu này nhằm đánh giá tác dụng hạ đường huyết của dịch chiết cồn 70 o của lá dây thìa canh, lá cỏ ngọt, vỏ quế, râu bắp và lá húng quế trên chuột ĐTĐ gây ra bởi streptozocin. ết quả chứng minh rằng cao lá dây th a canh và lá cỏ ngọt có khả na ng hạ đu ờng huyết đáng kể ở liều 5 mg kg so v i nhóm chuọ t đối chứng (P< 0,05). Trong đó, chuọ t uống cao lá dây th a canh và cỏ ngọt đường huyết tại thời điểm ngày thứ 21 giảm 57,68% và 54,93 so v i thời điểm giờ. hả na ng ức chế hoạt đọ ng của enzyme α-amylase và αglucosidase của cao cồn lá dây thìa canh và cỏ ngọt c ng đu ợc khảo sát in vitro. Kết quả cho thấy cao chiết cồn của dây thìa canh và cỏ ngọt Việt Nam đều có khả năng ức chế mạnh hoạt đọ ng của enzyme α-...

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This study attempts to investigate the awareness of SMEs in some northern provinces of Vietnam about online marketing, to determine the factors encouraging the SMEs to use online marketing channels, and to measure to what extent they influence the adoption. The quantitative method measures the intensity relationship between determinants in the Technology, Organization, and Environment (TOE) based theoretical model. In combination with it, the qualitative method is applied for the first phase of research exploration. Relying on the research model, a questionnaire is designed to survey 234 SMEs in some northern provinces of Vietnam. Multivariate regression is run with the help of software SPSS 22 to test which factors influence the adoption of online marketing. The result indicates that all three factors of the technological, organizational, and environmental context are drivers of online marketing for SMEs in some northern provinces of Vietnam. However, the organizational factor is the most important one. Based on these important results, the study proposes implications for SMEs to improve their marketing activities.

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