SummaryRemifentanil is increasingly being used as the primary agent to provide sedation during awake fibreoptic nasal intubation. In this observational study, we aimed to determine the optimal effect site concentration of remifentanil, using a target controlled infusion based on the Minto pharmacological model, to provide optimal safe intubation conditions without the use of other sedatives ⁄ premedication and ⁄ or spray-as-you-go local anaesthesia. Twenty patients with anticipated difficult airway participated in the study. Good intubating conditions were achieved in all patients with mean (SD) effect site concentration of 6.3 (3.87) ng.ml )1 of remifentanil recorded at nasal endoscopy and 8.06 (3.52) ng.ml )1 during tracheal intubation. No serious adverse event occurred during any of these procedures. These preliminary findings suggest that this is a feasible and safe technique for awake fibreoptic nasal intubation.

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Introduction: Percutaneous nephrolithotomy (PCNL) is already an established method of management of renal stone in Bangladesh. Initially the procedure was restricted to adult age group only. Percutaneous Nephrolithotomy is the choice of procedure for management of renal stone in paediatric age group. Objectives: To see the out come of stone clearance by Percutaneous Nephrolithotomy(PCNL)in paediatric age group. Methods: This was a study in single centre since January' 09 to December 201 1 . Total 1 1 cases of renal stone in paediatric age group were managed by PCNL. The age ranges from 4 years to 15years, average 8.47 years. We use pneumatic lithotripters. Nephrostomy tubes and D-J stent were used in 7 cases. In 4 cases only DJ stent were used. Postoperative haematocrit and creatinine was measured routinely. Results: Total stone clearance was achieved in all cases. The major post-operative complication was urosepsis(n-1), managed conservatively. Total hospital stay was 3 to 5 days; average 3.5 days. Stents were removed after 2 weeks. Conclusions: PCNL is a suitable procedure for the management of renal stone in pediatric age group this needs expertise, longer learning curve under supervised training. Journal of Surgical Sciences (2012) Vol. 16 (2) : 76-79

An experiment was conducted during 1999 and 2000 kharif seasons to know the right time of incorporation of groundnut crop residue and its subsequent effect on the following rice crop. The treatments of the experiment were five incorporation time of groundnut crop residue i.e., 12 days before transplanting (12 DBT), 9 DBT, 6 DBT, 3 DBT and 0 DBT of following T. aus rice along with a control (no incorporation of residue). The results showed that yield contributing characters and yield of T. aus rice varied significantly and increased with the increase of incorporation time. But incorporation at 3 days before transplanting performed worst due to seedling mortality by gas injury. The other incorporation time treatments gave identical grain yield (3.69-3.99 t ha -1 in1999 and 3.90-4.10 t ha -1 in 2000)and straw yield (3.89-4.67 t ha -1 in 1999 and 4.00-4.43 t ha -1 in 2000). The average highest grain yield (4.04 t ha -1 ) was obtained from the treatment 12 DBT.

Background. In the clinical setting, individuals have varying tolerance to hypovolemia induced by blood loss. Experimental generation of 0.1 Hz oscillations (~10-s cycle) in arterial pressure and cerebral blood flow via oscillatory lower body negative pressure (OLBNP) increases tolerance to this simulated hemorrhage, and protects cerebral tissue oxygenation. However, use of OLBNP as a method of inducing hemodynamic oscillations in the clinical setting is limited as: 1) it is a large and cumbersome technique, and; 2) it induces central hypovolemia, which would only worsen the magnitude of hemorrhage. In this study we evaluated a more clinically applicable method of inducing 0.1 Hz oscillations in arterial pressure and cerebral blood flow, using intermittent inflation of bilateral thigh cuffs. We hypothesized that the amplitude of arterial pressure and cerebral blood flow oscillations at 0.1 Hz would increase in response to repeated thigh cuff inflations at 0.1 Hz when compared with a baseline control condition. Methods. Ten healthy human subjects were tested (6 male, 4 female; 26.8 ± 4.1 y). Middle cerebral artery velocity (MCAv) was measured via transcranial doppler ultrasound, arterial pressure was measured via finger photoplethysmography, and end tidal CO2 (etCO2) was measured via capnography. Following a 10-min baseline period, intermittent thigh cuff inflations at 0.1 Hz and 230 mmHg (5-s inflation, 5-s deflation) were performed for 10-min (“oscillations”). 0.1 Hz oscillatory amplitude of mean arterial pressure and mean MCAv were quantified using Fast Fourier transformation during the last 5-min of baseline and the oscillatory period, and compared via two-tailed paired t-tests. Results. The amplitude of 0.1 Hz oscillations increased during the oscillatory period vs. baseline for mean arterial pressure (baseline: 1.7 ± 1.0 mmHg2 vs. oscillations: 9.0 ± 6.2 mmHg2; P = 0.004) and mean MCAv (baseline: 1.1 ± 0.6 (cm/s)2 vs. oscillations: 3.4 ± 3.1 (cm/s)2; P = 0.04). Absolute mean arterial pressure was similar between baseline and the oscillatory period (baseline: 97.2 ± 8.1 mmHg vs. oscillations: 99.1 ± 15.0 mmHg; P = 0.54), but absolute mean MCAv was lower during the oscillatory period (baseline: 61.7 ± 14.6 cm/s vs. oscillations: 53.2 ± 13.1 cm/s; P = 0.02). This reduction in mean MCAv was most likely due to hypocapnia (indexed by etCO2) induced by pacing the breathing of all subjects at ≥10 breaths/min (baseline: 33.2 ± 4.8 mmHg vs. oscillations 27.2 ± 4.5 mmHg; P = 0.005). Conclusions. Intermittent thigh cuff inflations at 0.1 Hz induced 0.1 Hz oscillations in both arterial pressure and cerebral blood flow when compared to baseline. These findings indicate that intermittent thigh cuff inflations could be developed as a method to induce pulsatile perfusion as a potential new therapy for individuals experiencing major blood loss. American Heart Association (Transformational Project Award) #19TPA34910073 and UNTHSC Physiology and Anatomy Seed Grant 2021 This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.