Composition of the Essential Oil of &lt;i&gt;Clausena Suffruticosa&lt;/i&gt; Leaf and Evaluation of its Antimicrobial and Cytotoxic Activities

Rahman, Anisur; Chakma, JS; Bhuiyan, NI; Islam, Saiful

doi:10.4314/tjpr.v11i5.6

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…[ 18 19 20 ] Important phytoconstituents of O. tenuiflorum and its phytochemical importance were summarized in Table 1 . [ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 ]…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Antidiabetic and Antihyperlipidemic Effects of Hydroalcoholic Extract of Leaves of Ocimum tenuiflorum (Lamiaceae) and Prediction of Biological Activity of its Phytoconstituents

Parasuraman¹,

Balamurugan²,

Christapher³

et al. 2015

Phcog Res

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Objective:The aim was to evaluate the anti-diabetic and anti-hyperlipidemic effects of hydroalcoholic extract of leaves of Ocimum tenuiflorum (Lamiaceae) and prediction of biological activities of its phytoconstituents using in vivo anti-diabetic model and in silico analysis respectively.Materials and Methods:The leaves of O. tenuiflorum were extracted with 60% ethanol, and the extract was used for further pharmacological screening. The acute toxicity of the extract was evaluated as per the guidelines set by the Organization for Economic Co-operation and Development, revised draft guidelines 423. The oral anti-diabetic activity of the hydroalcoholic extract of O. tenuiflorum (125, 250 and 500 mg/kg) was studied against streptozotocin (STZ) (50 mg/kg; i.p.) + nicotinamide (120 mg/kg; i.p.) induced diabetes mellitus. The animals were treated with the investigational plant extract and standard drug (glibenclamide) for 21 consecutive days and the effect of hydroalcoholic extract of O. tenuiflorum on blood glucose levels was measured at regular intervals. At the end of the study, blood samples were collected from all the animals for biochemical estimation, then the animals were sacrificed and the liver and kidney were collected for organ weight analysis. Prediction for pharmacological and toxicological properties of phytoconstituents of O. tenuiflorum was carried out using online web tools such as online pass prediction and lazar toxicity prediction.Results:The hydroalcoholic extract of O. tenuiflorum showed significant anti-diabetic and anti-hyperlipidemic activity at 250 and 500 mg/kg, and this effect was comparable with that of glibenclamide. Predicted biological activities of phytoconstituents of O. tenuiflorum showed presence of various pharmacological actions, which includes anti-diabetic and anti-hyperlipidemic activities. Prediction of toxicological properties of phytoconstituents of O. tenuiflorum did not show any major toxic effects.Conclusion:The hydroalcoholic extract of O. tenuiflorum showed significant anti-diabetic and anti-hyperlipidemic activity against STZ + nicotinamide induced diabetes mellitus in rats. Further studies are required to confirm the anti-diabetic and anti-hyperlipidemic activities of individual phytoconstituents of O. tenuiflorum.

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Section: Methodsmentioning

confidence: 99%

Evaluation of Antidiabetic and Antihyperlipidemic Effects of Hydroalcoholic Extract of Leaves of Ocimum tenuiflorum (Lamiaceae) and Prediction of Biological Activity of its Phytoconstituents

Parasuraman¹,

Balamurugan²,

Christapher³

et al. 2015

Phcog Res

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“…Herbal medicines are known to produce reliable pharmacological effects [9,17,18]. In the present study, hemostatic, antiinflammatory and antibacterial effects of sanqixiantao dressing were demonstrated in vivo and in vitro for the first time.…”

Section: Discussionmentioning

confidence: 76%

Hemostatic, anti-inflammatory and antibacterial effects of Sanqixiantao dressing <i>in vivo</i> and <i>in vitro</i>

Qin¹,

Hu²,

Wu³

et al. 2017

Trop. J. Pharm Res

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“…The chemical constituents of EOs from the plant Z. purpureum are particularly interesting in current studies. These EOs are well known for their antifungal, insecticidal, and antibacterial activities, which enable them to perform satisfactorily in protecting stored goods (Begum et al 2010, Rahman et al 2012. EOs are typically less dense than water, liquid, volatile, and rarely contain colored lipid-soluble compounds (Bhuiyan and Nahid 2023).…”

Section: Resultsmentioning

confidence: 99%

Gc-ms analysis of leaf and rhizome essential oil of zingiber purpureum roxb. From bangladesh

Nahid,

Bhuiyan

2024

Bangladesh J. Bot.

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Essential oils (EOs) are among the most important plant secondary metabolites. Zingiber purpureum Roxb. is a tropical ginger from Bangladesh, but its chemical constituents of leaves and rhizomes, both EOs, may have pharmacological effects. The aim of this study was carried out to analyze the qualitative composition of both Essential oils (EOs) of both leaf and rhizomes of Z. purpureum. The EOs from the leaves and rhizomes were extracted by hydrodistillation. Chemical constituents of the EOs were separated and identified by gas chromatography/mass spectrometry (GC/MS), and the relative percentage of each constituent was determined by area normalization. In total, 81 compounds were identified from leaf EOs, whereas 44 were from rhizome EOs. The common compounds identified from both rhizome and leaf EOs were triquinacene, 1,4, bis (methoxy), b-phellandrene and b-sesquiphellandrene, respectively. Besides, the major constituents of leaf EOs were sabinine (14.99%), b-pinene (14.32%), caryophyllene oxide (13.85%), and caryophyllene (9.47%), whereas the rhizome EOs confirmed (Z)-ocimene (21.97%), 4-terpineol (18.45%), γ-terpinene (3.86%) and cis-sabinenehydrate (3%). These EOs could be a promising source for the development of nutraceuticals, functional foods, and pharmaceutical products due to their potent activities and exploitation. Bangladesh J. Bot. 53(1): 153-158, 2024 (March)

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Composition of the Essential Oil of <i>Clausena Suffruticosa</i> Leaf and Evaluation of its Antimicrobial and Cytotoxic Activities

Cited by 4 publications

References 13 publications

Evaluation of Antidiabetic and Antihyperlipidemic Effects of Hydroalcoholic Extract of Leaves of Ocimum tenuiflorum (Lamiaceae) and Prediction of Biological Activity of its Phytoconstituents

Evaluation of Antidiabetic and Antihyperlipidemic Effects of Hydroalcoholic Extract of Leaves of Ocimum tenuiflorum (Lamiaceae) and Prediction of Biological Activity of its Phytoconstituents

Hemostatic, anti-inflammatory and antibacterial effects of Sanqixiantao dressing <i>in vivo</i> and <i>in vitro</i>

Gc-ms analysis of leaf and rhizome essential oil of zingiber purpureum roxb. From bangladesh

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