Hyperpigmentation is a skin problem caused by excessive melanin production due to continuous ultraviolet (UV) radiation. Kojic acid inhibiting melanin synthesis by tyrosinase enzyme is a prevalent treatment for hyperpigmentation. This study aims to determine the potential of chlorogenic acid and kojic acid as an anti-hyperpigmentation against tyrosinase using in silico molecular docking. The docking process involved optimizing chlorogenic acid and kojic acid structures, preparing tyrosinase protein (PDB ID: 5M8O), validating the molecular docking method, and docking of chlorogenic acid and kojic acid on tyrosinase. The binding energy of chlorogenic acid and kojic acid were -4.59 kcal/mol and -3.75 kcal/mol, while the binding energy of 0TR native ligand was -5.02 kcal/mol. The interaction of chlorogenic acid to tyrosinase involved ARG 321 and ARG 374 residues.  The results suggest that chlorogenic acid and kojic acid has the potential as anti-hyperpigmentation agents through inhibition of the tyrosinase enzyme.

Latar Belakang Penelitian: Diabetes melitus (DM) tergolong sebagai silent killer di masyarakat. Terapi insulin umumnya menjadi solusi penanganan DM, namun terdapat efek samping kenaikan berat badan akibat dampak hipoglikemik. Solusi lain yang diterapkan yaitu diet makanan berindeks glikemik rendah berupa beras analog. Bahan yang berpotensi dikembangkan sebagai beras analog yaitu umbi ubi jalar (Ipomoea batatas L.), dengan dietary fiber tinggi dan indeks glikemik rendah, serta fortifikasi antioksidan daun kelor (Moringa oleifera). Tujuan: Untuk memperbaharui pengetahuan terkini masyarakat terkait komposisi kimia bahan baku dan manfaat kesehatan untuk penderita DM, beserta teknologi pembuatan beras analog guna memperoleh hasil terbaik. Metode: Penelitian ini dilaksanakan dengan metode studi literatur (literature review) yang tergolong dalam penelitian deskriptif kualitatif secara sistematis. Hasil: Berbagai penelitian menunjukkan kedua bahan baku dilaporkan memiliki beragam senyawa kimia dan komponen nutrisi, indeks glikemik rendah, aktivitas antioksidan, serta anti-DM. Teknologi ekstrusi panas memberikan hasil terbaik dalam pembuatan beras analog. Kesimpulan: Produksi beras analog berbahan dasar umbi ubi jalar dan fortifikasi antioksidan daun kelor dengan ekstrusi panas berpotensi dikembangkan guna menghasilkan produk herbal fungsional sebagai upaya diversifikasi pangan penderita DM. Kata kunci: Ipomoea batatas L., Moringa oleifera, beras analog, fortifikasi, dan diabetes melitus

Breast cancer is the second cause of female death in the world. Lapatinib targeting HER-2 is the common inhibitor for breast cancer therapy. This study reports the potential of baicalin as an inhibitor of HER-2 through in silico molecular docking. The study was conducted by structure optimization of baicalin and lapatinib, preparation of HER-2 (PDB ID: 3PP0) target protein, validation of the molecular docking method, and docking of baicalin and lapatinib. The results showed that baicalin had an affinity for HER-2 with a binding energy of -6.0 kcal/mol, while the binding energy of the 03Q native ligand and lapatinib to HER-2 was -4.79 kcal/mol and -3.98 kcal/mol, respectively. This finding indicated that baicalin is a potential breast anticancer through the inhibition of the HER-2 protein.

Skin aging caused by excessive exposure to ultraviolet is known as photoaging. The mechanism underlying skin photoaging relates to collagen degradation in the extracellular matrix (ECM) by overexpression of matrix metalloproteinases-1 (MMP-1). Gallic acid is a phenolic antioxidant found in many types of plants and can be used as an anti-photoaging agent due to its antioxidant activity. This study aims to determine the potential effect of gallic acid as an anti-photoaging against MMP-1 using in silico molecular docking. The stages included gallic acid structure optimization using the HyperChem 8, preparation of protein target MMP-1 (PDB ID: 966C) using the Chimera1.10.1, validation the molecular docking protocol, and docking gallic acid on MMP-1 with the Autodock 1.5.6. The results showed that gallic acid had an affinity for MMP-1 with a binding energy of -6.0 kcal/mol. There are similar amino acid residues in hydrogen bonds between the native ligand RS2 with MMP-1 and gallic acid with MMP-1, namely ALA 182, LEU 181, and HIS 218. The results suggest that gallic acid has the potential as the anti-photoaging agent through the inhibition of the MMP-1 enzyme.